TY  - JOUR
TI  - Sensing of circulating cancer biomarkers with metal nanoparticles
AV  - public
SP  - 22152
VL  - 11
Y1  - 2019/12/14/
EP  - 22171
IS  - 46
N1  - This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.  https://creativecommons.org/licenses/by/3.0/
N2  - The analysis of circulating cancer biomarkers, including cell-free and circulating tumor DNA, circulating
tumor cells, microRNA and exosomes, holds promise in revolutionizing cancer diagnosis and prognosis
using body fluid analysis, also known as liquid biopsy. To enable clinical application of these biomarkers,
new analytical tools capable of detecting them in very low concentrations in complex sample matrixes
are needed. Metal nanoparticles have emerged as extraordinary analytical scaffolds because of their
unique optoelectronic properties and ease of functionalization. Hence, multiple analytical techniques
have been developed based on these nanoparticles and their plasmonic properties. The aim of this review
is to summarize and discuss the present development on the use of metal nanoparticles for the analysis
of circulating cancer biomarkers. We examine how metal nanoparticles can be used as (1) analytical transducers in various sensing principles, such as aggregation induced colorimetric assays, plasmon resonance
energy transfer, surface enhanced Raman spectroscopy, and refractive index sensing, and (2) signal
amplification elements in surface plasmon resonance spectroscopy and electrochemical detection. We
critically discuss the clinical relevance of each category of circulating biomarkers, followed by a thorough
analysis of how these nanoparticle-based designs have overcome some of the main challenges that gold
standard analytical techniques currently face, and what new directions the field may take in the future.
ID  - discovery10082709
UR  - https://doi.org/10.1039/c9nr03040a
SN  - 2040-3372
JF  - Nanoscale
A1  - Pallares, RM
A1  - Thanh, NTK
A1  - Su, X
ER  -