eprintid: 10082675
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/08/26/75
datestamp: 2019-10-01 11:12:04
lastmod: 2021-09-30 22:33:02
status_changed: 2019-10-01 11:12:04
type: article
metadata_visibility: show
creators_name: Quan, K
creators_name: Tanno, R
creators_name: Shipley, RJ
creators_name: Brown, JS
creators_name: Jacob, J
creators_name: Hurst, JR
creators_name: Hawkes, DJ
title: Reproducibility of an airway tapering measurement in computed tomography with application to bronchiectasis
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: K71
divisions: B04
divisions: C05
divisions: F48
divisions: F45
divisions: F42
keywords: tapering; computed tomography (CT) simulations; reproducibility; airways; CT metrology
note: Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution
or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.  https://creativecommons.org/licenses/by/4.0/
abstract: We propose a pipeline to acquire a scalar tapering measurement from the carina to the most distal
point of an individual airway visible on computed tomography (CT). We show the applicability of using tapering
measurements on clinically acquired data by quantifying the reproducibility of the tapering measure. We
generate a spline from the centerline of an airway to measure the area and arclength at contiguous intervals.
The tapering measurement is the gradient of the linear regression between area in log space and arclength. The
reproducibility of the measure was assessed by analyzing different radiation doses, voxel sizes, and reconstruction kernel on single timepoint and longitudinal CT scans and by evaluating the effect of airway bifurcations.
Using 74 airways from 10 CT scans, we show a statistical difference, p ¼ 3.4 × 10−4, in tapering between healthy
airways (n ¼ 35) and those affected by bronchiectasis (n ¼ 39). The difference between the mean of the two
populations is 0.011 mm−1, and the difference between the medians of the two populations was 0.006 mm−1.
The tapering measurement retained a 95% confidence interval of 0.005 mm−1 in a simulated 25 mAs scan and
retained a 95% confidence of 0.005 mm−1 on simulated CTs up to 1.5 times the original voxel size. We have
established an estimate of the precision of the tapering measurement and estimated the effect on precision of
the simulated voxel size and CT scan dose. We recommend that the scanner calibration be undertaken with the
phantoms as described, on the specific CT scanner, radiation dose, and reconstruction algorithm that are to be used in any quantitative studies
date: 2019-07
date_type: published
official_url: https://doi.org/10.1117/1.JMI.6.3.034003
oa_status: green
full_text_type: pub
pmcid: PMC6745534
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1697713
doi: 10.1117/1.JMI.6.3.034003
pii: 19024RR
lyricists_name: Brown, Jeremy
lyricists_name: Hawkes, David
lyricists_name: Hurst, John
lyricists_name: Jacob, Joseph
lyricists_name: Quan, Kenneth
lyricists_name: Shipley, Rebecca
lyricists_name: Tanno, Ryutaro
lyricists_id: JBROW91
lyricists_id: DJHAW78
lyricists_id: JHURS15
lyricists_id: JJACO76
lyricists_id: KQUAN55
lyricists_id: RSHIP58
lyricists_id: RTANN54
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Journal of Medical Imaging
volume: 6
number: 3
article_number: 034003
event_location: United States
issn: 2329-4302
citation:        Quan, K;    Tanno, R;    Shipley, RJ;    Brown, JS;    Jacob, J;    Hurst, JR;    Hawkes, DJ;      (2019)    Reproducibility of an airway tapering measurement in computed tomography with application to bronchiectasis.                   Journal of Medical Imaging , 6  (3)    , Article 034003.  10.1117/1.JMI.6.3.034003 <https://doi.org/10.1117/1.JMI.6.3.034003>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10082675/1/034003_1.pdf