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<https://discovery.ucl.ac.uk/id/eprint/10082675> <http://purl.org/dc/terms/title> "Reproducibility of an airway tapering measurement in computed tomography with application to bronchiectasis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10082675> <http://purl.org/ontology/bibo/abstract> "We propose a pipeline to acquire a scalar tapering measurement from the carina to the most distal\r\npoint of an individual airway visible on computed tomography (CT). We show the applicability of using tapering\r\nmeasurements on clinically acquired data by quantifying the reproducibility of the tapering measure. We\r\ngenerate a spline from the centerline of an airway to measure the area and arclength at contiguous intervals.\r\nThe tapering measurement is the gradient of the linear regression between area in log space and arclength. The\r\nreproducibility of the measure was assessed by analyzing different radiation doses, voxel sizes, and reconstruction kernel on single timepoint and longitudinal CT scans and by evaluating the effect of airway bifurcations.\r\nUsing 74 airways from 10 CT scans, we show a statistical difference, p ¼ 3.4 × 10−4, in tapering between healthy\r\nairways (n ¼ 35) and those affected by bronchiectasis (n ¼ 39). The difference between the mean of the two\r\npopulations is 0.011 mm−1, and the difference between the medians of the two populations was 0.006 mm−1.\r\nThe tapering measurement retained a 95% confidence interval of 0.005 mm−1 in a simulated 25 mAs scan and\r\nretained a 95% confidence of 0.005 mm−1 on simulated CTs up to 1.5 times the original voxel size. We have\r\nestablished an estimate of the precision of the tapering measurement and estimated the effect on precision of\r\nthe simulated voxel size and CT scan dose. We recommend that the scanner calibration be undertaken with the\r\nphantoms as described, on the specific CT scanner, radiation dose, and reconstruction algorithm that are to be used in any quantitative studies"^^<http://www.w3.org/2001/XMLSchema#string> .
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