eprintid: 10082408
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/10/08/24/08
datestamp: 2019-09-30 14:44:46
lastmod: 2021-09-20 22:26:49
status_changed: 2019-09-30 14:44:46
type: article
metadata_visibility: show
creators_name: Abo-zeid, Y
creators_name: Williams, G
title: The potential anti-infective applications of metal oxide nanoparticles: A systematic review
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Microbial infections present a major global healthcare challenge, in large part because of the development of microbial resistance to the currently approved antimicrobial drugs. This demands the development of new antimicrobial agents. Metal oxide nanoparticles (MONPs) are a class of materials that have been widely explored for diagnostic and therapeutic purposes. They are reported to have wide‐ranging antimicrobial activities and to be potent against bacteria, viruses, and protozoans. The use of MONPs reduces the possibility of resistance developing because they have multiple mechanisms of action (including via reactive oxygen species generation), simultaneously attacking many sites in the microorganism. However, despite this there are to date no MONPs clinically approved for antimicrobial therapy. This review explores the recent literature in this area, discusses the mechanisms of MONP action against microorganisms, and considers the barriers faced to the use of MONPs in humans. These include biological challenges, of which the potential for an immune response and off‐target toxicity are key. We explore in detail the possible benefits/disbenefits of an immune response being initiated, and consider the effect of production method (chemical vs. green synthesis) on cytotoxicity. There are also a number of technical and manufacturing challenges hindering MONP translation to the clinic which are additionally discussed in depth. In the short term, there are potentially some “quick wins” from the repurposing of already‐approved nanoparticle‐based medicines for anti‐infective applications, but a number of hurdles, both technical and biological, lie in the path to long‐term clinical translation of new MONP‐based formulations.

This article is categorized under:

Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
date: 2020-03
date_type: published
publisher: Wiley-Blackwell
official_url: https://doi.org/10.1002/wnan.1592
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1697383
doi: 10.1002/wnan.1592
lyricists_name: Williams, Gareth
lyricists_id: GWILL02
actors_name: Williams, Gareth
actors_id: GWILL02
actors_role: owner
full_text_status: public
publication: WIREs Nanomedicine and Nanobiotechnology
volume: 12
number: 2
article_number: e1592
issn: 1939-0041
citation:        Abo-zeid, Y;    Williams, G;      (2020)    The potential anti-infective applications of metal oxide nanoparticles: A systematic review.                   WIREs Nanomedicine and Nanobiotechnology , 12  (2)    , Article e1592.  10.1002/wnan.1592 <https://doi.org/10.1002/wnan.1592>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10082408/3/Williams_The%20potential%20anti-infective%20applications%20of%20metal%20oxide%20nanoparticles.%20A%20systematic%20review_AAM.pdf