eprintid: 10082087
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/08/20/87
datestamp: 2019-09-24 10:55:36
lastmod: 2021-09-26 23:12:29
status_changed: 2019-09-24 10:55:36
type: article
metadata_visibility: show
creators_name: Smith, V
creators_name: Vanhaecke, A
creators_name: Herrick, AL
creators_name: Distler, O
creators_name: Guerra, MG
creators_name: Denton, CP
creators_name: Deschepper, E
creators_name: Foeldvari, I
creators_name: Gutierrez, M
creators_name: Hachulla, E
creators_name: Ingegnoli, F
creators_name: Kubo, S
creators_name: Müller-Ladner, U
creators_name: Riccieri, V
creators_name: Sulli, A
creators_name: van Laar, JM
creators_name: Vonk, MC
creators_name: Walker, UA
creators_name: Cutolo, M
creators_name: EULAR Study Group on Microcirculation in Rheumatic Diseases, 
title: Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern"
ispublished: inpress
subjects: RFH
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G90
keywords: Algorithm, Capillaroscopy, EULAR Study Group on Microcirculation in Rheumatic Diseases, Experts, Novices, Reliability, “Scleroderma patterns”
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abstract: OBJECTIVES: This study was designed to propose a simple "Fast Track algorithm" for capillaroscopists of any level of experience to differentiate "scleroderma patterns" from "non-scleroderma patterns" on capillaroscopy and to assess its inter-rater reliability. METHODS: Based on existing definitions to categorise capillaroscopic images as "scleroderma patterns" and taking into account the real life variability of capillaroscopic images described standardly according to the European League Against Rheumatism (EULAR) Study Group on Microcirculation in Rheumatic Diseases, a fast track decision tree, the "Fast Track algorithm" was created by the principal expert (VS) to facilitate swift categorisation of an image as "non-scleroderma pattern (category 1)" or "scleroderma pattern (category 2)". Mean inter-rater reliability between all raters (experts/attendees) of the 8th EULAR course on capillaroscopy in Rheumatic Diseases (Genoa, 2018) and, as external validation, of the 8th European Scleroderma Trials and Research group (EUSTAR) course on systemic sclerosis (SSc) (Nijmegen, 2019) versus the principal expert, as well as reliability between the rater pairs themselves was assessed by mean Cohen's and Light's kappa coefficients. RESULTS: Mean Cohen's kappa was 1/0.96 (95% CI 0.95-0.98) for the 6 experts/135 attendees of the 8th EULAR capillaroscopy course and 1/0.94 (95% CI 0.92-0.96) for the 3 experts/85 attendees of the 8th EUSTAR SSc course. Light's kappa was 1/0.92 at the 8th EULAR capillaroscopy course, and 1/0.87 at the 8th EUSTAR SSc course. CONCLUSION: For the first time, a clinical expert based fast track decision algorithm has been developed to differentiate a "non-scleroderma" from a "scleroderma pattern" on capillaroscopic images, demonstrating excellent reliability when applied by capillaroscopists with varying levels of expertise versus the principal expert and corroborated with external validation.
date: 2019
date_type: published
official_url: https://doi.org/10.1016/j.autrev.2019.102394
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1696381
doi: 10.1016/j.autrev.2019.102394
pii: S1568-9972(19)30201-0
lyricists_name: Denton, Christopher
lyricists_id: CPDEN87
actors_name: Denton, Christopher
actors_id: CPDEN87
actors_role: owner
full_text_status: public
publication: Autoimmunity Reviews
article_number: 102394
event_location: Netherlands
issn: 1873-0183
citation:        Smith, V;    Vanhaecke, A;    Herrick, AL;    Distler, O;    Guerra, MG;    Denton, CP;    Deschepper, E;                                                     ... EULAR Study Group on Microcirculation in Rheumatic Diseases; + view all <#>        Smith, V;  Vanhaecke, A;  Herrick, AL;  Distler, O;  Guerra, MG;  Denton, CP;  Deschepper, E;  Foeldvari, I;  Gutierrez, M;  Hachulla, E;  Ingegnoli, F;  Kubo, S;  Müller-Ladner, U;  Riccieri, V;  Sulli, A;  van Laar, JM;  Vonk, MC;  Walker, UA;  Cutolo, M;  EULAR Study Group on Microcirculation in Rheumatic Diseases;   - view fewer <#>    (2019)    Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern".                   Autoimmunity Reviews      , Article 102394.  10.1016/j.autrev.2019.102394 <https://doi.org/10.1016/j.autrev.2019.102394>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10082087/1/Manuscript%20FastTrack_Final.pdf