%0 Journal Article
%@ 1464-5041
%A Brady, MC
%A Ali, M
%A VandenBerg, K
%A Williams, LJ
%A Williams, LR
%A Abo, M
%A Becker, F
%A Bowen, A
%A Brandenburg, C
%A Breitenstein, C
%A Bruehl, S
%A Copland, DA
%A Cranfill, TB
%A di Pietro-Bachmann, M
%A Enderby, P
%A Fillingham, J
%A Galli, FL
%A Gandolfi, M
%A Glize, B
%A Godecke, E
%A Hawkins, N
%A Hilari, K
%A Hinckley, J
%A Horton, S
%A Howard, D
%A Jaecks, P
%A Jefferies, E
%A Jesus, LMT
%A Kambanaros, M
%A Kang, EK
%A Khedr, EM
%A Kong, AP-H
%A Kukkonen, T
%A Laganaro, M
%A Ralph, MAL
%A Laska, AC
%A Leemann, B
%A Leff, AP
%A Lima, RR
%A Lorenz, A
%A MacWhinney, B
%A Marshall, RS
%A Mattioli, F
%A Mavis, I
%A Meinzer, M
%A Nilipour, R
%A Noe, E
%A Paik, N-J
%A Palmer, R
%A Papathanasiou, I
%A Patricio, BF
%A Martins, IP
%A Price, C
%A Jakovac, TP
%A Rochon, E
%A Rose, ML
%A Rosso, C
%A Rubi-Fessen, I
%A Ruiter, MB
%A Snell, C
%A Stahl, B
%A Szaflarski, JP
%A Thomas, SA
%A van de Sandt-Koenderman, M
%A van der Meulen, I
%A Visch-Brink, E
%A Worrall, L
%A Wright, HH
%D 2019
%F discovery:10081838
%I ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
%J Aphasiology
%K Science & Technology, Life Sciences & Biomedicine, Audiology & Speech-Language Pathology, Clinical Neurology, Rehabilitation, Neurosciences & Neurology, Stroke, aphasia, complex intervention, IPD, meta-analysis, EXTENSION STATEMENT, INTENSITY
%T RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
%U https://discovery.ucl.ac.uk/id/eprint/10081838/
%X Background: Speech and language therapy (SLT) benefits people  with aphasia following stroke. Group level summary statistics from  randomised controlled trials hinder exploration of highly complex  SLT interventions and a clinically relevant heterogeneous population.  Creating a database of individual participant data (IPD) for  people with aphasia aims to allow exploration of individual and  therapy-related predictors of recovery and prognosis.  Aim: To explore the contribution that individual participant characteristics  (including stroke and aphasia profiles) and SLT intervention  components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets  (including randomised controlled trials, non-randomised comparison  studies, observational studies and registries) and invite their  contribution to the database. Where possible, we will use metaand  network meta-analysis to explore language performance after  stroke and predictors of recovery as it relates to participants who  had no SLT, historical SLT or SLT in the primary research study. We  will also examine the components of effective SLT interventions.  Outcomes and results: Outcomes include changes in measures of  functional communication, overall severity of language impairment,  auditory comprehension, spoken language (including naming), reading  and writing from baseline. Data captured on assessment tools will  be collated and transformed to a standardised measure for each of  the outcome domains.  Conclusion: Our planned systematic-review-based IPD meta- and  network meta-analysis is a large scale, international, multidisciplinary  and methodologically complex endeavour. It will enable  hypotheses to be generated and tested to optimise and inform  development of interventions for people with aphasia after stroke.  Systematic review registration: The protocol has been registered  at the International Prospective Register of Systematic Reviews  (PROSPERO; registration number: CRD42018110947)
%Z This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License  (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any  medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.