eprintid: 10081780
rev_number: 30
eprint_status: archive
userid: 608
dir: disk0/10/08/17/80
datestamp: 2019-09-18 13:24:32
lastmod: 2021-09-17 22:25:06
status_changed: 2020-12-03 19:28:28
type: article
metadata_visibility: show
creators_name: Gasteiger, C
creators_name: Jones, ASK
creators_name: Kleinstäuber, M
creators_name: Lobo, M
creators_name: Horne, R
creators_name: Dalbeth, N
creators_name: Petrie, KJ
title: Effects of Message Framing on Patients’ Perceptions and Willingness to Change to a Biosimilar in a Hypothetical Drug Switch
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G11
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Objective:
Patients may hold negative perceptions towards biosimilars which can create barriers to their uptake. Physicians also report uncertainty in how best to explain biosimilars. The aim of this study was to measure the effect of differently framed explanations on patients’ perceptions of and willingness to change to a biosimilar in a hypothetical drug switch.

Methods:
Ninety‐six patients with rheumatic diseases taking an originator biologic were randomised to receive one of four biosimilar explanations ‐ positive framing with and without an analogy, and negative framing with and without an analogy. Willingness to switch to a biosimilar, perceptions about biosimilars, and the effectiveness of the explanation were measured after the information delivery.

Results:
Positive framing led to more participants being willing to switch (67%) than negative framing (46%). Framing significantly predicted willingness to switch to a biosimilar, with participants in the positive framing group being 2.36 times more willing to switch (P = 0.041). The positive framing group also reported significantly greater perceived efficacy of biosimilars (P = 0.046), and thought the explanation was more convincing (P = 0.030). The analogy did not enhance willingness to switch or understanding (P > 0.05).

Conclusion:
Positive framing can improve perceptions of and willingness to switch to a biosimilar in patients currently taking biologic treatments.
date: 2020-09
date_type: published
official_url: https://doi.org/10.1002/acr.24012
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1668027
doi: 10.1002/acr.24012
lyricists_name: Horne, Robert
lyricists_name: Jones, Annie Selina Kozlowski
lyricists_id: RHORN95
lyricists_id: AJONA85
actors_name: Austen, Jennifer
actors_id: JAUST66
actors_role: owner
full_text_status: public
publication: Arthritis Care and Research
volume: 72
number: 9
pagerange: 1323-1330
event_location: United States
issn: 2151-4658
citation:        Gasteiger, C;    Jones, ASK;    Kleinstäuber, M;    Lobo, M;    Horne, R;    Dalbeth, N;    Petrie, KJ;      (2020)    Effects of Message Framing on Patients’ Perceptions and Willingness to Change to a Biosimilar in a Hypothetical Drug Switch.                   Arthritis Care and Research , 72  (9)   pp. 1323-1330.    10.1002/acr.24012 <https://doi.org/10.1002/acr.24012>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10081780/3/Horne%20Biosimilars%20framing%20revised%20clean.pdf