eprintid: 10081637
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/08/16/37
datestamp: 2019-09-16 12:14:47
lastmod: 2021-10-07 22:06:21
status_changed: 2019-09-16 12:14:47
type: article
metadata_visibility: show
creators_name: Geeson, C
creators_name: Wei, L
creators_name: Franklin, BD
title: High-risk medicines associated with clinically relevant medication-related problems in United Kingdom hospitals: a prospective observational study
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G11
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: The aim of this prospective observational study was to establish associations between the use of high-risk medicine groups and the study outcome: occurrence of at least one moderate or severe preventable medication-related problem (MRP). Data on MRPs, high-risk medicines, and other potential risk factors were collected from adults on medical wards in two UK hospitals. Logistic regression modelling was used to determine relationships between high-risk medicines and the study outcome. Among 1,503 eligible admissions, six high-risk medicine groups were associated with the study outcome on univariable analysis; multivariable analysis found only systemic antimicrobials and epilepsy medicines to be independently associated with the outcome (adjusted odds ratio 1.44, 95% confidence interval 1.08-1.92 and adjusted odds ratio 1.61, 95% confidence interval 1.16-2.25 respectively). Identification of high-risk medicine groups has potential to permit targeting of patients at highest risk of avoidable medication-related harm, but multivariable analysis suggests risk is likely to be multifactorial.
date: 2020-01
date_type: published
official_url: https://doi.org/10.1111/bcp.14119
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1692821
doi: 10.1111/bcp.14119
lyricists_name: Franklin, Bryony
lyricists_name: Geeson, Cathy
lyricists_name: Wei, Li
lyricists_id: BFRAN90
lyricists_id: CAGEE05
lyricists_id: LWEIX32
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: British Journal of Clinical Pharmacology
volume: 86
number: 1
pagerange: 165-169
event_location: England
issn: 1365-2125
citation:        Geeson, C;    Wei, L;    Franklin, BD;      (2020)    High-risk medicines associated with clinically relevant medication-related problems in United Kingdom hospitals: a prospective observational study.                   British Journal of Clinical Pharmacology , 86  (1)   pp. 165-169.    10.1111/bcp.14119 <https://doi.org/10.1111/bcp.14119>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10081637/1/Geeson_et_al-2019-British_Journal_of_Clinical_Pharmacology.pdf