%P 165-169
%C England
%L discovery10081637
%V 86
%J British Journal of Clinical Pharmacology
%N 1
%A C Geeson
%A L Wei
%A BD Franklin
%X The aim of this prospective observational study was to establish associations between the use of high-risk medicine groups and the study outcome: occurrence of at least one moderate or severe preventable medication-related problem (MRP). Data on MRPs, high-risk medicines, and other potential risk factors were collected from adults on medical wards in two UK hospitals. Logistic regression modelling was used to determine relationships between high-risk medicines and the study outcome. Among 1,503 eligible admissions, six high-risk medicine groups were associated with the study outcome on univariable analysis; multivariable analysis found only systemic antimicrobials and epilepsy medicines to be independently associated with the outcome (adjusted odds ratio 1.44, 95% confidence interval 1.08-1.92 and adjusted odds ratio 1.61, 95% confidence interval 1.16-2.25 respectively). Identification of high-risk medicine groups has potential to permit targeting of patients at highest risk of avoidable medication-related harm, but multivariable analysis suggests risk is likely to be multifactorial.
%T High-risk medicines associated with clinically relevant medication-related problems in United Kingdom hospitals: a prospective observational study
%O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
%D 2020