@article{discovery10081637,
           pages = {165--169},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
          volume = {86},
         journal = {British Journal of Clinical Pharmacology},
           title = {High-risk medicines associated with clinically relevant medication-related problems in United Kingdom hospitals: a prospective observational study},
            year = {2020},
           month = {January},
          number = {1},
            issn = {1365-2125},
        abstract = {The aim of this prospective observational study was to establish associations between the use of high-risk medicine groups and the study outcome: occurrence of at least one moderate or severe preventable medication-related problem (MRP). Data on MRPs, high-risk medicines, and other potential risk factors were collected from adults on medical wards in two UK hospitals. Logistic regression modelling was used to determine relationships between high-risk medicines and the study outcome. Among 1,503 eligible admissions, six high-risk medicine groups were associated with the study outcome on univariable analysis; multivariable analysis found only systemic antimicrobials and epilepsy medicines to be independently associated with the outcome (adjusted odds ratio 1.44, 95\% confidence interval 1.08-1.92 and adjusted odds ratio 1.61, 95\% confidence interval 1.16-2.25 respectively). Identification of high-risk medicine groups has potential to permit targeting of patients at highest risk of avoidable medication-related harm, but multivariable analysis suggests risk is likely to be multifactorial.},
          author = {Geeson, C and Wei, L and Franklin, BD},
             url = {https://doi.org/10.1111/bcp.14119}
}