eprintid: 10081006
rev_number: 39
eprint_status: archive
userid: 608
dir: disk0/10/08/10/06
datestamp: 2019-09-04 12:44:06
lastmod: 2021-09-22 22:23:54
status_changed: 2019-10-01 16:50:29
type: article
metadata_visibility: show
creators_name: Smpokou, E
creators_name: González-Quiroz, M
creators_name: Martins, C
creators_name: Alvito, P
creators_name: Le Blond, J
creators_name: Glaser, J
creators_name: Aragón, A
creators_name: Wesseling, C
creators_name: Nitsch, D
creators_name: Pearce, N
creators_name: Norman, J
creators_name: Lindh, C
creators_name: Morton, J
creators_name: Caplin, B
title: Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican Nephropathy
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G93
divisions: D16
keywords: Chronic Kidney Disease of unknown origin (CKDu), nephrotoxicity, pesticides, Mesoamerican Nephropathy (MeN), environmental toxins
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: OBJECTIVES: There is an epidemic of Mesoamerican Nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN, was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months, and decline in kidney function over 2 years. // METHODS: Urine samples collected at baseline (pre-sugarcane harvest) and the first 6-month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (Al, total As, Cd, Co, Cr, Cu, Hg, Mn, Pb, Se, Si and Sr) were analysed by inductively-coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-D, 3-PBA, 4F3PBA, CFCA, DCCA, ETU, glyphosate, MCPA, OH-PYM, 5-OH-TBZ, TEB-OH and TCP), and two mycotoxins (OTA and CIT), were analysed by liquid chromatography coupled mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable versus declining kidney function) were examined. // RESULTS: Elevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection. // CONCLUSIONS: The tested metals, metalloids, pesticides and mycotoxins were not associated with loss of kidney function in participants at-risk of MeN.
date: 2019-12
date_type: published
publisher: BMJ Publishing Group
official_url: http://dx.doi.org/10.1136/oemed-2019-105772
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1687966
doi: 10.1136/oemed-2019-105772
lyricists_name: Caplin, Benjamin
lyricists_name: Gonzalez Quiroz, Marvin
lyricists_name: Norman, Jill
lyricists_name: Smpokou Olney, Evangelia
lyricists_id: BCAPL88
lyricists_id: MAGON25
lyricists_id: JTNOR32
lyricists_id: ETSMP45
actors_name: Stacey, Thomas
actors_id: TSSTA20
actors_role: owner
full_text_status: public
publication: Occupational and Environmental Medicine
volume: 76
number: 12
pagerange: 920-926
issn: 1351-0711
citation:        Smpokou, E;    González-Quiroz, M;    Martins, C;    Alvito, P;    Le Blond, J;    Glaser, J;    Aragón, A;                             ... Caplin, B; + view all <#>        Smpokou, E;  González-Quiroz, M;  Martins, C;  Alvito, P;  Le Blond, J;  Glaser, J;  Aragón, A;  Wesseling, C;  Nitsch, D;  Pearce, N;  Norman, J;  Lindh, C;  Morton, J;  Caplin, B;   - view fewer <#>    (2019)    Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican Nephropathy.                   Occupational and Environmental Medicine , 76  (12)   pp. 920-926.    10.1136/oemed-2019-105772 <https://doi.org/10.1136/oemed-2019-105772>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10081006/1/Smpokou%20OEM%20revision_final.pdf