TY  - JOUR
N2  - An algorithm for the simulation of two-dimensional spectral domain optical coherence tomography images based on Maxwell?s equations is presented. A recently developed and modified time-harmonic numerical solution of Maxwell?s equations is used to obtain scattered far fields for many wave numbers contained in the calculated spectrum. The interferometer setup with its lenses is included rigorously with Fresnel integrals and the Debye-Wolf integral. The implemented model is validated with an existing FDTD algorithm by comparing simulated tomograms of single and multiple cylindrical scatterers for perpendicular and parallel polarisation of the incident light. Tomograms are presented for different realisations of multiple cylindrical scatterers. Furthermore, simulated tomograms of a ziggurat-shaped scatterer and of dentin slabs, with varying scatterer concentrations, are investigated. It is shown that the tomograms do not represent the physical structures present within the sample.
ID  - discovery10080886
UR  - https://doi.org/10.1038/s41598-019-48498-2
SN  - 2045-2322
JF  - Scientific Reports
A1  - Brenner, T
A1  - Munro, PRT
A1  - Krüger, B
A1  - Kienle, A
KW  - Computational biophysics
KW  -  Computational science
KW  -  Imaging and  sensing
TI  - Two-dimensional simulation of optical coherence tomography images
AV  - public
VL  - 9
Y1  - 2019/08/21/
N1  - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article?s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article?s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
ER  -