eprintid: 10080597 rev_number: 24 eprint_status: archive userid: 608 dir: disk0/10/08/05/97 datestamp: 2019-08-29 10:28:55 lastmod: 2021-09-17 22:57:35 status_changed: 2019-08-29 10:28:55 type: article metadata_visibility: show creators_name: Fatourou, EM creators_name: Tsochatzis, EA title: Management of metabolic syndrome and cardiovascular risk after liver transplantation ispublished: pub subjects: RFH divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G91 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Cardiovascular events are the second most prevalent cause of non-hepatic mortality in liver transplant recipients. The incidence of these events is projected to rise because of the growing prevalence of non-alcoholic steatohepatitis as a transplant indication and the ageing population of liver transplant recipients. Recipients with metabolic syndrome are up to four times more likely to have a cardiovascular event than recipients without, therefore prevention and optimal treatment of the components of metabolic syndrome are key in reducing the risk of these events. Although data on the treatment of metabolic comorbidities specifically in liver transplant recipients are scarce, there is detailed guidance from learned societies that mostly mirrors the guidance for patients at increased cardiovascular risk in the general population. In this Review, we discuss the management of the components of metabolic syndrome following liver transplantation and provide practical stepwise guidance. We also emphasise the need for adequately powered studies for the treatment of metabolic comorbidities in liver transplant recipients. date: 2019-09 date_type: published publisher: ELSEVIER INC official_url: https://doi.org/10.1016/S2468-1253(19)30181-5 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1680445 doi: 10.1016/S2468-1253(19)30181-5 lyricists_name: Tsochatzis, Emmanouil lyricists_id: ETSOC40 actors_name: Allington-Smith, Dominic actors_id: DAALL44 actors_role: owner full_text_status: public publication: The Lancet Gastroenterology and Hepatology volume: 4 number: 9 pagerange: 731-741 pages: 11 issn: 2468-1253 citation: Fatourou, EM; Tsochatzis, EA; (2019) Management of metabolic syndrome and cardiovascular risk after liver transplantation. The Lancet Gastroenterology and Hepatology , 4 (9) pp. 731-741. 10.1016/S2468-1253(19)30181-5 <https://doi.org/10.1016/S2468-1253%2819%2930181-5>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10080597/3/Tsochatzis_CV%20MS%20LGH%20R1%20clear%202019.pdf