eprintid: 10079834
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/07/98/34
datestamp: 2019-08-20 09:40:06
lastmod: 2021-12-13 01:59:20
status_changed: 2019-08-20 09:40:06
type: article
metadata_visibility: show
creators_name: Dunn, DT
creators_name: Glidden, DV
title: The Connection between the Averted Infections Ratio and the Rate Ratio in Active-control Trials of Pre-exposure Prophylaxis Agents
ispublished: pub
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
keywords: hiv, non-inferiority, active-control trials
note: his work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. https://creativecommons.org/licenses/by-nc-nd/4.0/
abstract: The design and analysis of active-control trials to evaluate experimental HIV pre-exposure prophylaxis (PrEP)
agents pose serious statistical challenges. We recently proposed a new outcome measure, the averted infections
ratio (AIR) – the proportion of infections that would be averted by using the experimental agent rather than the
control agent (compared to no intervention). The main aim of the current paper is to examine the mathematical
connection between AIR and the HIV incidence rate ratio, the standard outcome measure. We also consider
the sample size implications of the choice of primary outcome measure and explore the connection between
effectiveness and efficacy under a simplified model of adherence.
date: 2019-07-12
date_type: published
publisher: Walter de Gruyter GmbH
official_url: https://doi.org/10.1515/scid-2019-0006
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1682460
doi: 10.1515/scid-2019-0006
lyricists_name: Dunn, David
lyricists_id: DTDUN70
actors_name: Dunn, David
actors_id: DTDUN70
actors_role: owner
full_text_status: public
publication: Statistical Communications in Infectious Diseases
volume: 11
number: 1
article_number: 20190006
issn: 1948-4690
citation:        Dunn, DT;    Glidden, DV;      (2019)    The Connection between the Averted Infections Ratio and the Rate Ratio in Active-control Trials of Pre-exposure Prophylaxis Agents.                   Statistical Communications in Infectious Diseases , 11  (1)    , Article 20190006.  10.1515/scid-2019-0006 <https://doi.org/10.1515/scid-2019-0006>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10079834/1/%5BStatistical%20Communications%20in%20Infectious%20Diseases%5D%20The%20Connection%20between%20the%20Averted%20Infections%20Ratio%20and%20the%20Rate%20Ratio%20in%20Active-control%20Trials%20of%20Pre-exposure%20Prophylaxis%20Agents.pdf