eprintid: 10079604
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/07/96/04
datestamp: 2019-08-12 16:57:29
lastmod: 2021-12-24 23:10:58
status_changed: 2019-08-12 16:57:29
type: article
metadata_visibility: show
creators_name: Okamoto, M
creators_name: Shipley, MJ
creators_name: Wilkinson, IB
creators_name: McEniery, CM
creators_name: Valencia-Hernández, CA
creators_name: Singh-Manoux, A
creators_name: Kivimaki, M
creators_name: Brunner, EJ
title: Does Poorer Pulmonary Function Accelerate Arterial Stiffening?
ispublished: inpress
divisions: UCL
divisions: B02
divisions: D12
divisions: G19
keywords: epidemiology, inflammation, longitudinal study, respiratory function
note: © 2019 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
abstract: Whether poorer pulmonary function accelerates progression of arterial stiffness remains unknown as prior observational studies have not examined longitudinal changes in arterial stiffness in relation to earlier pulmonary function. Data (N=5342, 26% female) were drawn from the Whitehall II cohort study. Participants completed repeated assessments of forced expiratory volume in 1 second (FEV1, L) and carotid-femoral pulse wave velocity (cf-PWV, m/s) over 5 years. The effect of FEV1 on later cf-PWV and its progression was estimated using linear mixed-effects modeling. Possible explanatory mechanisms, such as mediation by low-grade systemic inflammation, common-cause explanation by preexisting cardiometabolic risk factors, and reverse-causation bias, were assessed. Poorer pulmonary function was associated with later higher cf-PWV and its subsequent progression (cf-PWV 5-year change 0.09, 95% CI 0.03-0.17 per SD lower FEV1) after adjustment for age, sex, ethnicity, heart rate, and mean arterial pressure. Decrease in pulmonary function was associated with later higher cf-PWV (0.17, 95% CI 0.04-0.30 in the top compared to bottom quartile of decline in FEV1). There was no evidence to support mediation by circulating CRP (C-reactive protein) or IL (interleukin)-6. Furthermore, arterial stiffness was not associated with later FEV1 after accounting for cardiometabolic status. In conclusion, poorer pulmonary function predicted future arterial stiffness. These findings support pulmonary function as a clinically important risk factor for arterial stiffness and provide justification for future intervention studies for pulmonary function based on its relationship with arterial stiffness.
date: 2019-10
date_type: published
official_url: https://doi.org/10.1161/HYPERTENSIONAHA.119.13183
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1680012
doi: 10.1161/HYPERTENSIONAHA.119.13183
lyricists_name: Brunner, Eric
lyricists_name: Kivimaki, Mika
lyricists_name: Shipley, Martin
lyricists_name: Singh-Manoux, Archana
lyricists_id: EJBRU90
lyricists_id: MJKIV95
lyricists_id: MJSHI88
lyricists_id: ASING25
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Hypertension
issn: 1524-4563
citation:        Okamoto, M;    Shipley, MJ;    Wilkinson, IB;    McEniery, CM;    Valencia-Hernández, CA;    Singh-Manoux, A;    Kivimaki, M;           Okamoto, M;  Shipley, MJ;  Wilkinson, IB;  McEniery, CM;  Valencia-Hernández, CA;  Singh-Manoux, A;  Kivimaki, M;  Brunner, EJ;   - view fewer <#>    (2019)    Does Poorer Pulmonary Function Accelerate Arterial Stiffening?                   Hypertension        10.1161/HYPERTENSIONAHA.119.13183 <https://doi.org/10.1161/HYPERTENSIONAHA.119.13183>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10079604/1/HYPERTENSIONAHA.119.13183.pdf