eprintid: 10079604 rev_number: 27 eprint_status: archive userid: 608 dir: disk0/10/07/96/04 datestamp: 2019-08-12 16:57:29 lastmod: 2021-12-24 23:10:58 status_changed: 2019-08-12 16:57:29 type: article metadata_visibility: show creators_name: Okamoto, M creators_name: Shipley, MJ creators_name: Wilkinson, IB creators_name: McEniery, CM creators_name: Valencia-Hernández, CA creators_name: Singh-Manoux, A creators_name: Kivimaki, M creators_name: Brunner, EJ title: Does Poorer Pulmonary Function Accelerate Arterial Stiffening? ispublished: inpress divisions: UCL divisions: B02 divisions: D12 divisions: G19 keywords: epidemiology, inflammation, longitudinal study, respiratory function note: © 2019 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited. abstract: Whether poorer pulmonary function accelerates progression of arterial stiffness remains unknown as prior observational studies have not examined longitudinal changes in arterial stiffness in relation to earlier pulmonary function. Data (N=5342, 26% female) were drawn from the Whitehall II cohort study. Participants completed repeated assessments of forced expiratory volume in 1 second (FEV1, L) and carotid-femoral pulse wave velocity (cf-PWV, m/s) over 5 years. The effect of FEV1 on later cf-PWV and its progression was estimated using linear mixed-effects modeling. Possible explanatory mechanisms, such as mediation by low-grade systemic inflammation, common-cause explanation by preexisting cardiometabolic risk factors, and reverse-causation bias, were assessed. Poorer pulmonary function was associated with later higher cf-PWV and its subsequent progression (cf-PWV 5-year change 0.09, 95% CI 0.03-0.17 per SD lower FEV1) after adjustment for age, sex, ethnicity, heart rate, and mean arterial pressure. Decrease in pulmonary function was associated with later higher cf-PWV (0.17, 95% CI 0.04-0.30 in the top compared to bottom quartile of decline in FEV1). There was no evidence to support mediation by circulating CRP (C-reactive protein) or IL (interleukin)-6. Furthermore, arterial stiffness was not associated with later FEV1 after accounting for cardiometabolic status. In conclusion, poorer pulmonary function predicted future arterial stiffness. These findings support pulmonary function as a clinically important risk factor for arterial stiffness and provide justification for future intervention studies for pulmonary function based on its relationship with arterial stiffness. date: 2019-10 date_type: published official_url: https://doi.org/10.1161/HYPERTENSIONAHA.119.13183 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1680012 doi: 10.1161/HYPERTENSIONAHA.119.13183 lyricists_name: Brunner, Eric lyricists_name: Kivimaki, Mika lyricists_name: Shipley, Martin lyricists_name: Singh-Manoux, Archana lyricists_id: EJBRU90 lyricists_id: MJKIV95 lyricists_id: MJSHI88 lyricists_id: ASING25 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Hypertension issn: 1524-4563 citation: Okamoto, M; Shipley, MJ; Wilkinson, IB; McEniery, CM; Valencia-Hernández, CA; Singh-Manoux, A; Kivimaki, M; Okamoto, M; Shipley, MJ; Wilkinson, IB; McEniery, CM; Valencia-Hernández, CA; Singh-Manoux, A; Kivimaki, M; Brunner, EJ; - view fewer <#> (2019) Does Poorer Pulmonary Function Accelerate Arterial Stiffening? Hypertension 10.1161/HYPERTENSIONAHA.119.13183 <https://doi.org/10.1161/HYPERTENSIONAHA.119.13183>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10079604/1/HYPERTENSIONAHA.119.13183.pdf