eprintid: 10078598 rev_number: 28 eprint_status: archive userid: 608 dir: disk0/10/07/85/98 datestamp: 2019-07-24 10:42:16 lastmod: 2021-12-02 00:29:39 status_changed: 2019-07-24 10:42:16 type: article metadata_visibility: show creators_name: Pontecorboli, G creators_name: Biglino, G creators_name: Milano, EG creators_name: Sophocleous, F creators_name: Biffi, B creators_name: Dastidar, AG creators_name: Schievano, S creators_name: Di Mario, C creators_name: Bucciarelli-Ducci, C title: Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA1 keywords: Takotsubo cardiomyopathy, cardiac magnetic resonance, computational modelling, myocardial deformation, statistical shape modelling note: © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) abstract: Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission ("early TCM") showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that "early TCM" LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity. date: 2019 date_type: published official_url: https://doi.org/10.1080/10255842.2019.1632836 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1672374 doi: 10.1080/10255842.2019.1632836 lyricists_name: Schievano, Silvia lyricists_id: SSCHI22 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Computer Methods in Biomechanics and Biomedical Engineering volume: 22 number: 14 pagerange: 1103-1106 event_location: England citation: Pontecorboli, G; Biglino, G; Milano, EG; Sophocleous, F; Biffi, B; Dastidar, AG; Schievano, S; ... Bucciarelli-Ducci, C; + view all <#> Pontecorboli, G; Biglino, G; Milano, EG; Sophocleous, F; Biffi, B; Dastidar, AG; Schievano, S; Di Mario, C; Bucciarelli-Ducci, C; - view fewer <#> (2019) Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy. Computer Methods in Biomechanics and Biomedical Engineering , 22 (14) pp. 1103-1106. 10.1080/10255842.2019.1632836 <https://doi.org/10.1080/10255842.2019.1632836>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10078598/19/Schievano_Beyond%20apical%20ballooning.%20Computational%20modelling%20reveals%20morphological%20features%20of%20Takotsubo%20cardiomyopathy_VoR.pdf