eprintid: 10078598
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/07/85/98
datestamp: 2019-07-24 10:42:16
lastmod: 2021-12-02 00:29:39
status_changed: 2019-07-24 10:42:16
type: article
metadata_visibility: show
creators_name: Pontecorboli, G
creators_name: Biglino, G
creators_name: Milano, EG
creators_name: Sophocleous, F
creators_name: Biffi, B
creators_name: Dastidar, AG
creators_name: Schievano, S
creators_name: Di Mario, C
creators_name: Bucciarelli-Ducci, C
title: Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA1
keywords: Takotsubo cardiomyopathy, cardiac magnetic resonance, computational modelling, myocardial deformation, statistical shape modelling
note: © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/)
abstract: Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission ("early TCM") showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that "early TCM" LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity.
date: 2019
date_type: published
official_url: https://doi.org/10.1080/10255842.2019.1632836
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1672374
doi: 10.1080/10255842.2019.1632836
lyricists_name: Schievano, Silvia
lyricists_id: SSCHI22
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Computer Methods in Biomechanics and Biomedical Engineering
volume: 22
number: 14
pagerange: 1103-1106
event_location: England
citation:        Pontecorboli, G;    Biglino, G;    Milano, EG;    Sophocleous, F;    Biffi, B;    Dastidar, AG;    Schievano, S;         ... Bucciarelli-Ducci, C; + view all <#>        Pontecorboli, G;  Biglino, G;  Milano, EG;  Sophocleous, F;  Biffi, B;  Dastidar, AG;  Schievano, S;  Di Mario, C;  Bucciarelli-Ducci, C;   - view fewer <#>    (2019)    Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy.                   Computer Methods in Biomechanics and Biomedical Engineering , 22  (14)   pp. 1103-1106.    10.1080/10255842.2019.1632836 <https://doi.org/10.1080/10255842.2019.1632836>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10078598/19/Schievano_Beyond%20apical%20ballooning.%20Computational%20modelling%20reveals%20morphological%20features%20of%20Takotsubo%20cardiomyopathy_VoR.pdf