eprintid: 10078521 rev_number: 16 eprint_status: archive userid: 608 dir: disk0/10/07/85/21 datestamp: 2019-07-23 11:37:31 lastmod: 2021-09-25 23:18:48 status_changed: 2019-07-23 11:37:31 type: article metadata_visibility: show creators_name: Bajo, VM creators_name: Nodal, FR creators_name: Korn, C creators_name: Constantinescu, AO creators_name: Mann, EO creators_name: Boyden, ES creators_name: King, AJ title: Silencing cortical activity during sound-localization training impairs auditory perceptual learning ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F81 note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. abstract: The brain has a remarkable capacity to adapt to changes in sensory inputs and to learn from experience. However, the neural circuits responsible for this flexible processing remain poorly understood. Using optogenetic silencing of ArchT-expressing neurons in adult ferrets, we show that within-trial activity in primary auditory cortex (A1) is required for training-dependent recovery in sound-localization accuracy following monaural deprivation. Because localization accuracy under normal-hearing conditions was unaffected, this highlights a specific role for cortical activity in learning. A1-dependent plasticity appears to leave a memory trace that can be retrieved, facilitating adaptation during a second period of monaural deprivation. However, in ferrets in which learning was initially disrupted by perturbing A1 activity, subsequent optogenetic suppression during training no longer affected localization accuracy when one ear was occluded. After the initial learning phase, the reweighting of spatial cues that primarily underpins this plasticity may therefore occur in A1 target neurons. date: 2019-07-12 date_type: published official_url: https://doi.org/10.1038/s41467-019-10770-4 oa_status: green full_text_type: pub pmcid: PMC6625986 language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1673501 doi: 10.1038/s41467-019-10770-4 pii: 10.1038/s41467-019-10770-4 lyricists_name: Constantinescu, Alexandra lyricists_id: AOCON22 actors_name: Constantinescu, Alexandra actors_id: AOCON22 actors_role: owner full_text_status: public publication: Nature Communications volume: 10 article_number: 3075 event_location: England issn: 2041-1723 citation: Bajo, VM; Nodal, FR; Korn, C; Constantinescu, AO; Mann, EO; Boyden, ES; King, AJ; (2019) Silencing cortical activity during sound-localization training impairs auditory perceptual learning. Nature Communications , 10 , Article 3075. 10.1038/s41467-019-10770-4 <https://doi.org/10.1038/s41467-019-10770-4>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10078521/1/41467_2019_Article_10770.pdf