eprintid: 10078521
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/07/85/21
datestamp: 2019-07-23 11:37:31
lastmod: 2021-09-25 23:18:48
status_changed: 2019-07-23 11:37:31
type: article
metadata_visibility: show
creators_name: Bajo, VM
creators_name: Nodal, FR
creators_name: Korn, C
creators_name: Constantinescu, AO
creators_name: Mann, EO
creators_name: Boyden, ES
creators_name: King, AJ
title: Silencing cortical activity during sound-localization training impairs auditory perceptual learning
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F81
note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
abstract: The brain has a remarkable capacity to adapt to changes in sensory inputs and to learn from experience. However, the neural circuits responsible for this flexible processing remain poorly understood. Using optogenetic silencing of ArchT-expressing neurons in adult ferrets, we show that within-trial activity in primary auditory cortex (A1) is required for training-dependent recovery in sound-localization accuracy following monaural deprivation. Because localization accuracy under normal-hearing conditions was unaffected, this highlights a specific role for cortical activity in learning. A1-dependent plasticity appears to leave a memory trace that can be retrieved, facilitating adaptation during a second period of monaural deprivation. However, in ferrets in which learning was initially disrupted by perturbing A1 activity, subsequent optogenetic suppression during training no longer affected localization accuracy when one ear was occluded. After the initial learning phase, the reweighting of spatial cues that primarily underpins this plasticity may therefore occur in A1 target neurons.
date: 2019-07-12
date_type: published
official_url: https://doi.org/10.1038/s41467-019-10770-4
oa_status: green
full_text_type: pub
pmcid: PMC6625986
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1673501
doi: 10.1038/s41467-019-10770-4
pii: 10.1038/s41467-019-10770-4
lyricists_name: Constantinescu, Alexandra
lyricists_id: AOCON22
actors_name: Constantinescu, Alexandra
actors_id: AOCON22
actors_role: owner
full_text_status: public
publication: Nature Communications
volume: 10
article_number: 3075
event_location: England
issn: 2041-1723
citation:        Bajo, VM;    Nodal, FR;    Korn, C;    Constantinescu, AO;    Mann, EO;    Boyden, ES;    King, AJ;      (2019)    Silencing cortical activity during sound-localization training impairs auditory perceptual learning.                   Nature Communications , 10     , Article 3075.  10.1038/s41467-019-10770-4 <https://doi.org/10.1038/s41467-019-10770-4>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10078521/1/41467_2019_Article_10770.pdf