TY  - INPR
AV  - public
KW  - Depression
KW  -  Facial expressions
KW  -  Emotion recognition
KW  -  Cognition
KW  -  Cohort study
N2  - Objective: Cognitive theories suggest people with depression interpret self-referential social information negatively. However, it is unclear whether these biases precede or follow depression. We investigated whether facial
expression recognition was associated with depressive symptoms cross-sectionally and longitudinally.
Methods: Prospective cohort study of people who had visited UK primary care in the past year reporting depressive symptoms (n = 509). Depressive symptoms were measured using the Patient Health Questionnaire
(PHQ-9) at four time-points, 2 weeks apart. A computerised task assessed happy and sad facial expression recognition at three time-points (n = 505 at time 1). The unbiased hit rate measured ability to recognise emotions
accounting for any general tendency to identify the emotion when it was not present.
Results: The sample included the full range of depressive symptom severity, with 45% meeting diagnostic criteria for depression. There was no evidence that happy or sad unbiased hit rates were associated with concurrent
or subsequent depressive symptoms. There was weak evidence that, for every additional face incorrectly classified as happy, concurrent PHQ-9 scores reduced by 0.05 of a point (95% CI = -0.10 to 0.002, p = 0.06 after
adjustment for confounders). This association was strongest for more ambiguous facial expressions (interaction
term p<0.001).
Limitations: This was an observational study with relatively short follow-up (6 weeks) and small changes in
depressive symptoms and emotion recognition. Only 7% of invited patients consented to participate.
Conclusions: Reduced misclassifications of ambiguous faces as happy could be a state marker of depression, but
was not associated with subsequent depressive symptoms. Future research should focus on the interpretation of
ambiguous social information
A1  - Bone, JK
A1  - Lewis, G
A1  - Button, KS
A1  - Duffy, L
A1  - Harmer, CJ
A1  - Munafт, MR
A1  - Penton-Voak, IS
A1  - Wiles, NJ
A1  - Lewis, G
SN  - 1573-2517
EP  - 469
SP  - 461
VL  - 257
JF  - Journal of Affective Disorders
Y1  - 2019/10/01/
UR  - https://doi.org/10.1016/j.jad.2019.06.025
ID  - discovery10078515
N1  - This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
TI  - Variation in recognition of happy and sad facial expressions and self-reported depressive symptom severity: A prospective cohort study
ER  -