@article{discovery10076717,
         journal = {Lab on a Chip},
            year = {2019},
           title = {Cell sorting actuated by a microfluidic inertial vortex},
            note = {{\copyright} The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/).},
           month = {June},
            issn = {1473-0189},
          author = {Pritchard, RH and Zhukov, AA and Fullerton, JN and Want, AJ and Hussain, F and la Cour, MF and Bashtanov, ME and Gold, RD and Hailes, A and Banham-Hall, E and Rogers, SS},
        abstract = {The sorting of specific cell populations is an established tool in biological research, with new applications demanding greater cell throughput, sterility and elimination of cross-contamination. Here we report 'vortex-actuated cell sorting' (VACS), a new technique that deflects cells individually, via the generation of a transient microfluidic vortex by a thermal vapour bubble: a novel mechanism, which is able to sort cells based on fluorescently-labelled molecular markers. Using in silico simulation and experiments on beads, an immortal cell line and human peripheral blood mononuclear cells (PBMCs), we demonstrate high-purity and high-recovery sorting with input rates up to 10{\^{ }}\{4\} cells per s and switching speeds comparable to existing techniques ({\ensuremath{>}}40 kHz). A tiny footprint (1 {$\times$} 0.25 mm) affords miniaturization and the potential to achieve multiplexing: a crucial step in increasing processing rate. Simple construction using biocompatible materials potentially minimizes cost of fabrication and permits single-use sterile cartridges. We believe VACS potentially enables parallel sorting at throughputs relevant to cell therapy, liquid biopsy and phenotypic screening.},
             url = {http://dx.doi.org/10.1039/c9lc00120d}
}