<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10075617> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/title> "Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/abstract> "Background: Increasing numbers of healthy individuals are undergoing predispositional personal genome\r\nsequencing. Here we describe the design and early outcomes of the PeopleSeq Consortium, a multi-cohort\r\ncollaboration of predispositional genome sequencing projects, which is examining the medical, behavioral, and\r\neconomic outcomes of returning genomic sequencing information to healthy individuals.\r\nMethods: Apparently healthy adults who participated in four of the sequencing projects in the Consortium were\r\nincluded. Web-based surveys were administered before and after genomic results disclosure, or in some cases only\r\nafter results disclosure. Surveys inquired about sociodemographic characteristics, motivations and concerns, behavioral\r\nand medical responses to sequencing results, and perceived utility.\r\nResults: Among 1395 eligible individuals, 658 enrolled in the Consortium when contacted and 543 have completed a\r\nsurvey after receiving their genomic results thus far (mean age 53.0 years, 61.4% male, 91.7% white, 95.5% college\r\ngraduates). Most participants (98.1%) were motivated to undergo sequencing because of curiosity about their genetic\r\nmake-up. The most commonly reported concerns prior to pursuing sequencing included how well the results would\r\npredict future risk (59.2%) and the complexity of genetic variant interpretation (56.8%), while 47.8% of participants were\r\nconcerned about the privacy of their genetic information. Half of participants reported discussing their genomic results\r\nwith a healthcare provider during a median of 8.0 months after receiving the results; 13.5% reported making an\r\nadditional appointment with a healthcare provider specifically because of their results. Few participants (< 10%)\r\nreported making changes to their diet, exercise habits, or insurance coverage because of their results. Many\r\nparticipants (39.5%) reported learning something new to improve their health that they did not know before.\r\nReporting regret or harm from the decision to undergo sequencing was rare (< 3.0%).\r\nConclusions: Healthy individuals who underwent predispositional sequencing expressed some concern around\r\nprivacy prior to pursuing sequencing, but were enthusiastic about their experience and not distressed by their results.\r\nWhile reporting value in their health-related results, few participants reported making medical or lifestyle changes."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/date> "2019-02-27" . <https://discovery.ucl.ac.uk/id/document/913078> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/volume> "11" . <https://discovery.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> <http://xmlns.com/foaf/0.1/name> "BMC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> . <https://discovery.ucl.ac.uk/id/publication/ext-1756994X> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-1756994X> <http://xmlns.com/foaf/0.1/name> "Genome Medicine"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-1756994X> . <https://discovery.ucl.ac.uk/id/publication/ext-1756994X> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:1756994X> . <https://discovery.ucl.ac.uk/id/publication/ext-1756994X> <http://purl.org/ontology/bibo/issn> "1756994X" . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-97ebcd8223d29f4c6679521d264c8cbb> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-97ebcd8223d29f4c6679521d264c8cbb> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9ba10995857b7d717cafbce2f240177c> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-9ba10995857b7d717cafbce2f240177c> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-30731672dac55c1f1213e81094051590> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-30731672dac55c1f1213e81094051590> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1edfcd652f222bcac9f9fef39f8c3d77> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-1edfcd652f222bcac9f9fef39f8c3d77> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-48514d8aa0395a1e4acaa2f44bb275b3> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-48514d8aa0395a1e4acaa2f44bb275b3> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-448e809d9309acdd19a7aa1d1f5cb1f9> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-448e809d9309acdd19a7aa1d1f5cb1f9> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4bc8d38c9712b4c3f404bdc27e5f84eb> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-4bc8d38c9712b4c3f404bdc27e5f84eb> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-118887c12a31bf51db4b2a2c39ec8888> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-118887c12a31bf51db4b2a2c39ec8888> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-aa0aba2da81414f0edb8f7a2f704af66> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-aa0aba2da81414f0edb8f7a2f704af66> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d1545c97e0f20205de639d1ae4ba3809> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d1545c97e0f20205de639d1ae4ba3809> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7b61ef6d4725e434cc28a0197447ef53> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-7b61ef6d4725e434cc28a0197447ef53> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-35d81831ea547277cef5ab563746c0f3> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-35d81831ea547277cef5ab563746c0f3> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7db0b7d5f03d47e39da0d9073d92b239> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-7db0b7d5f03d47e39da0d9073d92b239> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bc9c56e337dc91b9b7de60910ff02bf1> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-bc9c56e337dc91b9b7de60910ff02bf1> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c2bacfddaab2d7a9d05da60a6f52a212> . <https://discovery.ucl.ac.uk/id/eprint/10075617> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> . <https://discovery.ucl.ac.uk/id/eprint/10075617#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-c2bacfddaab2d7a9d05da60a6f52a212> . <https://discovery.ucl.ac.uk/id/person/ext-30731672dac55c1f1213e81094051590> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-30731672dac55c1f1213e81094051590> <http://xmlns.com/foaf/0.1/givenName> "MA"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-30731672dac55c1f1213e81094051590> <http://xmlns.com/foaf/0.1/familyName> "McGinniss"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-30731672dac55c1f1213e81094051590> <http://xmlns.com/foaf/0.1/name> "MA McGinniss"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c2bacfddaab2d7a9d05da60a6f52a212> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c2bacfddaab2d7a9d05da60a6f52a212> <http://xmlns.com/foaf/0.1/givenName> "RC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c2bacfddaab2d7a9d05da60a6f52a212> <http://xmlns.com/foaf/0.1/familyName> "Green"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c2bacfddaab2d7a9d05da60a6f52a212> <http://xmlns.com/foaf/0.1/name> "RC Green"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-35d81831ea547277cef5ab563746c0f3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-35d81831ea547277cef5ab563746c0f3> <http://xmlns.com/foaf/0.1/givenName> "EE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-35d81831ea547277cef5ab563746c0f3> <http://xmlns.com/foaf/0.1/familyName> "Schadt"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-35d81831ea547277cef5ab563746c0f3> <http://xmlns.com/foaf/0.1/name> "EE Schadt"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-448e809d9309acdd19a7aa1d1f5cb1f9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-448e809d9309acdd19a7aa1d1f5cb1f9> <http://xmlns.com/foaf/0.1/givenName> "GM"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-448e809d9309acdd19a7aa1d1f5cb1f9> <http://xmlns.com/foaf/0.1/familyName> "Church"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-448e809d9309acdd19a7aa1d1f5cb1f9> <http://xmlns.com/foaf/0.1/name> "GM Church"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9ba10995857b7d717cafbce2f240177c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9ba10995857b7d717cafbce2f240177c> <http://xmlns.com/foaf/0.1/givenName> "MD"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9ba10995857b7d717cafbce2f240177c> <http://xmlns.com/foaf/0.1/familyName> "Linderman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9ba10995857b7d717cafbce2f240177c> <http://xmlns.com/foaf/0.1/name> "MD Linderman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc9c56e337dc91b9b7de60910ff02bf1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-bc9c56e337dc91b9b7de60910ff02bf1> <http://xmlns.com/foaf/0.1/givenName> "SD"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc9c56e337dc91b9b7de60910ff02bf1> <http://xmlns.com/foaf/0.1/familyName> "Crawford"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc9c56e337dc91b9b7de60910ff02bf1> <http://xmlns.com/foaf/0.1/name> "SD Crawford"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d1545c97e0f20205de639d1ae4ba3809> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d1545c97e0f20205de639d1ae4ba3809> <http://xmlns.com/foaf/0.1/givenName> "CT"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d1545c97e0f20205de639d1ae4ba3809> <http://xmlns.com/foaf/0.1/familyName> "Caskey"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d1545c97e0f20205de639d1ae4ba3809> <http://xmlns.com/foaf/0.1/name> "CT Caskey"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-aa0aba2da81414f0edb8f7a2f704af66> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-aa0aba2da81414f0edb8f7a2f704af66> <http://xmlns.com/foaf/0.1/givenName> "AL"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-aa0aba2da81414f0edb8f7a2f704af66> <http://xmlns.com/foaf/0.1/familyName> "McGuire"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-aa0aba2da81414f0edb8f7a2f704af66> <http://xmlns.com/foaf/0.1/name> "AL McGuire"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7db0b7d5f03d47e39da0d9073d92b239> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7db0b7d5f03d47e39da0d9073d92b239> <http://xmlns.com/foaf/0.1/givenName> "DE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7db0b7d5f03d47e39da0d9073d92b239> <http://xmlns.com/foaf/0.1/familyName> "Nielsen"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7db0b7d5f03d47e39da0d9073d92b239> <http://xmlns.com/foaf/0.1/name> "DE 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