eprintid: 10075580
rev_number: 26
eprint_status: archive
userid: 608
dir: disk0/10/07/55/80
datestamp: 2019-06-14 17:46:13
lastmod: 2021-12-03 23:21:49
status_changed: 2019-06-14 17:46:13
type: article
metadata_visibility: show
creators_name: Hubacek, JA
creators_name: Pikhart, H
creators_name: Peasey, A
creators_name: Malyutina, S
creators_name: Pajak, A
creators_name: Tamosiunas, A
creators_name: Voevoda, M
creators_name: Holmes, MV
creators_name: Bobak, M
title: The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study
ispublished: pub
divisions: UCL
divisions: B02
divisions: D12
divisions: G19
keywords: ADH1B, Alcohol intake, Binge drinking, FTO, Polymorphism, Sex, Smoking
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: Alcohol intake and tobacco smoking have significant negative health consequences and both are influenced by genetic predispositions. Some studies suggest that the FTO gene is associated with alcohol consumption. We investigated whether a tagging variant (rs17817449) within the FTO gene is associated with alcohol intake, problem drinking and smoking behaviour. METHODS: We analysed data from 26,792 Caucasian adults (47.2% of males; mean age 58.9 (±7.3) years), examined through the prospective cohort HAPIEE study. The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the FTO and ADH1B genes. RESULTS: We found no significant association of the FTO polymorphism with smoking status in either sex. The associations of the FTO polymorphism with drinking pattern were inconsistent and differed by gender. In men, GG homozygote carriers had lower odds of problem drinking (OR 0.85, 95% CI 0.75-0.96, p = 0.03). In women, the combination of the FTO/ADH1B GG/+A genotypes doubled the risk of binge drinking (OR 2.10, 95% CI 1.19-3.71, p < 0.05), and the risk was further increased among smoking women (OR 4.10, 95% CI 1.64-10.24, p = 0.008). CONCLUSIONS: In this large population study, the FTO gene appeared associated with binge and problem drinking, and the associations were modified by sex, smoking status and the ADH1B polymorphism.
date: 2019-07-30
date_type: published
official_url: https://doi.org/10.1016/j.gene.2019.05.002
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1653738
doi: 10.1016/j.gene.2019.05.002
pii: S0378-1119(19)30457-3
lyricists_name: Bobak, Martin
lyricists_name: Peasey, Anne
lyricists_name: Pikhart, Hynek
lyricists_id: MBOBA10
lyricists_id: AEPEA49
lyricists_id: HPIKH73
actors_name: Nonhebel, Lucinda
actors_id: LNONH33
actors_role: owner
full_text_status: public
publication: Gene
volume: 707
pagerange: 30-35
issn: 1879-0038
citation:        Hubacek, JA;    Pikhart, H;    Peasey, A;    Malyutina, S;    Pajak, A;    Tamosiunas, A;    Voevoda, M;         ... Bobak, M; + view all <#>        Hubacek, JA;  Pikhart, H;  Peasey, A;  Malyutina, S;  Pajak, A;  Tamosiunas, A;  Voevoda, M;  Holmes, MV;  Bobak, M;   - view fewer <#>    (2019)    The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study.                   Gene , 707    pp. 30-35.    10.1016/j.gene.2019.05.002 <https://doi.org/10.1016/j.gene.2019.05.002>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10075580/1/Pikhart_Hubacek%20D-18-04455%20revised.pdf