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<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/terms/title> "Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/ontology/bibo/abstract> "Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits reversible fragment screening, but such electrophilic fragments were considered nonselective and were rarely screened. We hypothesized that mild electrophiles might overcome the selectivity challenge and constructed a library of 993 mildly electrophilic fragments. We characterized this library by a new high-throughput thiol-reactivity assay and screened them against 10 cysteine-containing proteins. Highly reactive and promiscuous fragments were rare and could be easily eliminated. In contrast, we found hits for most targets. Combining our approach with high-throughput crystallography allowed rapid progression to potent and selective probes for two enzymes, the deubiquitinase OTUB2 and the pyrophosphatase NUDT7. No inhibitors were previously known for either. This study highlights the potential of electrophile-fragment screening as a practical and efficient tool for covalent-ligand discovery."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/terms/date> "2019" .
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<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1cce7909462a88662b8d33b12e8c2d0c> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075310#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10075310#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_31> <https://discovery.ucl.ac.uk/id/person/ext-1cce7909462a88662b8d33b12e8c2d0c> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f8e73f011f13621b9f4f56af433208d2> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075310#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10075310#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_32> <https://discovery.ucl.ac.uk/id/person/ext-f8e73f011f13621b9f4f56af433208d2> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6e379065746b14801df811d0523a1ded> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075310#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10075310#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_33> <https://discovery.ucl.ac.uk/id/person/ext-6e379065746b14801df811d0523a1ded> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b53acc5410270b5100e7393d2a83b3b5> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10075310#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10075310#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_34> <https://discovery.ucl.ac.uk/id/person/ext-b53acc5410270b5100e7393d2a83b3b5> .
<https://discovery.ucl.ac.uk/id/person/ext-b53acc5410270b5100e7393d2a83b3b5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b53acc5410270b5100e7393d2a83b3b5> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b53acc5410270b5100e7393d2a83b3b5> <http://xmlns.com/foaf/0.1/familyName> "London"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b53acc5410270b5100e7393d2a83b3b5> <http://xmlns.com/foaf/0.1/name> "N London"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d72c9f6bbfe5a59fbf8ecb94af2b5aa6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d72c9f6bbfe5a59fbf8ecb94af2b5aa6> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d72c9f6bbfe5a59fbf8ecb94af2b5aa6> <http://xmlns.com/foaf/0.1/familyName> "Gabizon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d72c9f6bbfe5a59fbf8ecb94af2b5aa6> <http://xmlns.com/foaf/0.1/name> "R Gabizon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1cce7909462a88662b8d33b12e8c2d0c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1cce7909462a88662b8d33b12e8c2d0c> <http://xmlns.com/foaf/0.1/givenName> "PE"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1cce7909462a88662b8d33b12e8c2d0c> <http://xmlns.com/foaf/0.1/familyName> "Brennan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1cce7909462a88662b8d33b12e8c2d0c> <http://xmlns.com/foaf/0.1/name> "PE Brennan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b0a394d5e6340755d14c68263c47a3ae> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b0a394d5e6340755d14c68263c47a3ae> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b0a394d5e6340755d14c68263c47a3ae> <http://xmlns.com/foaf/0.1/familyName> "Krojer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b0a394d5e6340755d14c68263c47a3ae> <http://xmlns.com/foaf/0.1/name> "T Krojer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e811c7c19f58615b51410ae6eb92e64e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e811c7c19f58615b51410ae6eb92e64e> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e811c7c19f58615b51410ae6eb92e64e> <http://xmlns.com/foaf/0.1/familyName> "Szommer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e811c7c19f58615b51410ae6eb92e64e> <http://xmlns.com/foaf/0.1/name> "T Szommer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dee35bbb2f93d90e12e25e8ba54eb475> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dee35bbb2f93d90e12e25e8ba54eb475> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dee35bbb2f93d90e12e25e8ba54eb475> <http://xmlns.com/foaf/0.1/familyName> "Reznik"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dee35bbb2f93d90e12e25e8ba54eb475> <http://xmlns.com/foaf/0.1/name> "N Reznik"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9f4fd9cadf82bc7338946f3ff8dececc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9f4fd9cadf82bc7338946f3ff8dececc> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9f4fd9cadf82bc7338946f3ff8dececc> <http://xmlns.com/foaf/0.1/familyName> "Guo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9f4fd9cadf82bc7338946f3ff8dececc> <http://xmlns.com/foaf/0.1/name> "J Guo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7391c1b16a31ed1b814412189db5d302> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7391c1b16a31ed1b814412189db5d302> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7391c1b16a31ed1b814412189db5d302> <http://xmlns.com/foaf/0.1/familyName> "Zaidman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7391c1b16a31ed1b814412189db5d302> <http://xmlns.com/foaf/0.1/name> "D Zaidman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8738c2eb94fca142d22ae69ab6695597> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8738c2eb94fca142d22ae69ab6695597> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8738c2eb94fca142d22ae69ab6695597> <http://xmlns.com/foaf/0.1/familyName> "Gan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8738c2eb94fca142d22ae69ab6695597> <http://xmlns.com/foaf/0.1/name> "J Gan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d36f35c82dd69ee55d0f773ab4d113> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d36f35c82dd69ee55d0f773ab4d113> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d36f35c82dd69ee55d0f773ab4d113> <http://xmlns.com/foaf/0.1/familyName> "Plotnikov"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d36f35c82dd69ee55d0f773ab4d113> <http://xmlns.com/foaf/0.1/name> "A Plotnikov"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-79a9e868a140a03acc2558408d4ba430> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-79a9e868a140a03acc2558408d4ba430> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-79a9e868a140a03acc2558408d4ba430> <http://xmlns.com/foaf/0.1/familyName> "Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-79a9e868a140a03acc2558408d4ba430> <http://xmlns.com/foaf/0.1/name> "Y Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ee7ad2e7d3f1503c8c1db8637c64e47d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ee7ad2e7d3f1503c8c1db8637c64e47d> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ee7ad2e7d3f1503c8c1db8637c64e47d> <http://xmlns.com/foaf/0.1/familyName> "Fairhead"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ee7ad2e7d3f1503c8c1db8637c64e47d> <http://xmlns.com/foaf/0.1/name> "M Fairhead"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3f84d971c26dba18e885b9844d507935> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3f84d971c26dba18e885b9844d507935> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3f84d971c26dba18e885b9844d507935> <http://xmlns.com/foaf/0.1/familyName> "Aimon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3f84d971c26dba18e885b9844d507935> <http://xmlns.com/foaf/0.1/name> "A Aimon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d81bc3d20dcf1be91251bb6f27d7ab96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d81bc3d20dcf1be91251bb6f27d7ab96> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d81bc3d20dcf1be91251bb6f27d7ab96> <http://xmlns.com/foaf/0.1/familyName> "Bennett"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d81bc3d20dcf1be91251bb6f27d7ab96> <http://xmlns.com/foaf/0.1/name> "J Bennett"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a28207043a32798a0a2dff7621529484> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a28207043a32798a0a2dff7621529484> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a28207043a32798a0a2dff7621529484> <http://xmlns.com/foaf/0.1/familyName> "Douangamath"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a28207043a32798a0a2dff7621529484> <http://xmlns.com/foaf/0.1/name> "A Douangamath"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1486a46d9b9ba8c44f7c3b4fcec09398> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1486a46d9b9ba8c44f7c3b4fcec09398> <http://xmlns.com/foaf/0.1/givenName> "AR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1486a46d9b9ba8c44f7c3b4fcec09398> <http://xmlns.com/foaf/0.1/familyName> "Coker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1486a46d9b9ba8c44f7c3b4fcec09398> <http://xmlns.com/foaf/0.1/name> "AR Coker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8b71c7ef419c2ec2eb2bcfd9f964fb5d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8b71c7ef419c2ec2eb2bcfd9f964fb5d> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8b71c7ef419c2ec2eb2bcfd9f964fb5d> <http://xmlns.com/foaf/0.1/familyName> "Velupillai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8b71c7ef419c2ec2eb2bcfd9f964fb5d> <http://xmlns.com/foaf/0.1/name> "S Velupillai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-08571c081fe5991c2a75004b822ab777> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-08571c081fe5991c2a75004b822ab777> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-08571c081fe5991c2a75004b822ab777> <http://xmlns.com/foaf/0.1/familyName> "Bradley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-08571c081fe5991c2a75004b822ab777> <http://xmlns.com/foaf/0.1/name> "A Bradley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a04e4654fd1728903ded2349c5f9830f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a04e4654fd1728903ded2349c5f9830f> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a04e4654fd1728903ded2349c5f9830f> <http://xmlns.com/foaf/0.1/familyName> "Resnick"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a04e4654fd1728903ded2349c5f9830f> <http://xmlns.com/foaf/0.1/name> "E Resnick"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-477c5c2da82df80fac436c42760fc92d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-477c5c2da82df80fac436c42760fc92d> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-477c5c2da82df80fac436c42760fc92d> <http://xmlns.com/foaf/0.1/familyName> "Amitai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-477c5c2da82df80fac436c42760fc92d> <http://xmlns.com/foaf/0.1/name> "G Amitai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ae4bd6750f15fc868c64274d44af8d0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9ae4bd6750f15fc868c64274d44af8d0> <http://xmlns.com/foaf/0.1/givenName> "GF"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ae4bd6750f15fc868c64274d44af8d0> <http://xmlns.com/foaf/0.1/familyName> "Ruda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ae4bd6750f15fc868c64274d44af8d0> <http://xmlns.com/foaf/0.1/name> "GF Ruda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-96a245e0e8a0eaaead067a6f349d114e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-96a245e0e8a0eaaead067a6f349d114e> <http://xmlns.com/foaf/0.1/givenName> "VM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-96a245e0e8a0eaaead067a6f349d114e> <http://xmlns.com/foaf/0.1/familyName> "Straub"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-96a245e0e8a0eaaead067a6f349d114e> <http://xmlns.com/foaf/0.1/name> "VM Straub"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f8e73f011f13621b9f4f56af433208d2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f8e73f011f13621b9f4f56af433208d2> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f8e73f011f13621b9f4f56af433208d2> <http://xmlns.com/foaf/0.1/familyName> "Ovaa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f8e73f011f13621b9f4f56af433208d2> <http://xmlns.com/foaf/0.1/name> "H Ovaa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e379065746b14801df811d0523a1ded> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6e379065746b14801df811d0523a1ded> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e379065746b14801df811d0523a1ded> <http://xmlns.com/foaf/0.1/familyName> "von Delft"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e379065746b14801df811d0523a1ded> <http://xmlns.com/foaf/0.1/name> "F von Delft"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00d240db923e4dead1a8730124d7a30e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-00d240db923e4dead1a8730124d7a30e> <http://xmlns.com/foaf/0.1/givenName> "CG"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00d240db923e4dead1a8730124d7a30e> <http://xmlns.com/foaf/0.1/familyName> "Dowson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-00d240db923e4dead1a8730124d7a30e> <http://xmlns.com/foaf/0.1/name> "CG Dowson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1baaaf86b2ce1aa2e666a1bae899440> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a1baaaf86b2ce1aa2e666a1bae899440> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1baaaf86b2ce1aa2e666a1bae899440> <http://xmlns.com/foaf/0.1/familyName> "Bellini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1baaaf86b2ce1aa2e666a1bae899440> <http://xmlns.com/foaf/0.1/name> "D Bellini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db6f11a94a10cb8234e9758b5c262078> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-db6f11a94a10cb8234e9758b5c262078> <http://xmlns.com/foaf/0.1/givenName> "KVM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db6f11a94a10cb8234e9758b5c262078> <http://xmlns.com/foaf/0.1/familyName> "Huber"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db6f11a94a10cb8234e9758b5c262078> <http://xmlns.com/foaf/0.1/name> "KVM Huber"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d3644c9d1ce52aaf5a9687721f29b1e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1d3644c9d1ce52aaf5a9687721f29b1e> <http://xmlns.com/foaf/0.1/givenName> "HM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d3644c9d1ce52aaf5a9687721f29b1e> <http://xmlns.com/foaf/0.1/familyName> "Barr"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d3644c9d1ce52aaf5a9687721f29b1e> <http://xmlns.com/foaf/0.1/name> "HM Barr"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31550dc476edb8c8f0570cedff085d3c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-31550dc476edb8c8f0570cedff085d3c> <http://xmlns.com/foaf/0.1/givenName> "PP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31550dc476edb8c8f0570cedff085d3c> <http://xmlns.com/foaf/0.1/familyName> "Geurink"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31550dc476edb8c8f0570cedff085d3c> <http://xmlns.com/foaf/0.1/name> "PP Geurink"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-18b3227e5d069e7e0d4696d4d2f4d4d5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-18b3227e5d069e7e0d4696d4d2f4d4d5> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-18b3227e5d069e7e0d4696d4d2f4d4d5> <http://xmlns.com/foaf/0.1/familyName> "Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-18b3227e5d069e7e0d4696d4d2f4d4d5> <http://xmlns.com/foaf/0.1/name> "C Wang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5c43bf8e535aacb7f762059162d39cbb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5c43bf8e535aacb7f762059162d39cbb> <http://xmlns.com/foaf/0.1/givenName> "O"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5c43bf8e535aacb7f762059162d39cbb> <http://xmlns.com/foaf/0.1/familyName> "Fedorov"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5c43bf8e535aacb7f762059162d39cbb> <http://xmlns.com/foaf/0.1/name> "O Fedorov"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba2cc2c2e0d71a90af9843edb9e31141> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ba2cc2c2e0d71a90af9843edb9e31141> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba2cc2c2e0d71a90af9843edb9e31141> <http://xmlns.com/foaf/0.1/familyName> "Díaz-Sáez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba2cc2c2e0d71a90af9843edb9e31141> <http://xmlns.com/foaf/0.1/name> "L Díaz-Sáez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ab9c2b73ae2d310537407f56a716028f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ab9c2b73ae2d310537407f56a716028f> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ab9c2b73ae2d310537407f56a716028f> <http://xmlns.com/foaf/0.1/familyName> "Sethi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ab9c2b73ae2d310537407f56a716028f> <http://xmlns.com/foaf/0.1/name> "R Sethi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/document/911517> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
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<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/911517> .
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<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/911519> .
<https://discovery.ucl.ac.uk/id/document/911519> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
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<https://discovery.ucl.ac.uk/id/document/911519> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/911520> .
<https://discovery.ucl.ac.uk/id/document/911520> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/911520> <http://www.w3.org/2000/01/rdf-schema#label> "Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/911520> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/document/911520> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
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<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/911521> .
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<https://discovery.ucl.ac.uk/id/document/911521> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/document/911521> <http://eprints.org/relation/issmallThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/911522> .
<https://discovery.ucl.ac.uk/id/document/911522> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
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<https://discovery.ucl.ac.uk/id/document/911522> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/document/911522> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/document/911522> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/eprint/10075310> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/911523> .
<https://discovery.ucl.ac.uk/id/document/911523> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
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<https://discovery.ucl.ac.uk/id/document/911523> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
<https://discovery.ucl.ac.uk/id/document/911523> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/911517> .
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<https://discovery.ucl.ac.uk/id/eprint/10075310/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #10075310 \n\nRapid Covalent-Probe Discovery by Electrophile-Fragment Screening\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/10075310/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/10075310/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10075310> .