eprintid: 10074494
rev_number: 31
eprint_status: archive
userid: 608
dir: disk0/10/07/44/94
datestamp: 2019-05-21 09:15:56
lastmod: 2021-09-19 23:03:23
status_changed: 2019-05-21 09:15:56
type: article
metadata_visibility: show
creators_name: Fung, SSM
creators_name: Stewart, RMK
creators_name: Dhallu, SK
creators_name: Sim, DA
creators_name: Keane, PA
creators_name: Wilkins, MR
creators_name: Tuft, SJ
title: Anterior Segment Optical Coherence Tomographic Angiography Assessment of Acute Chemical Injury
ispublished: pub
subjects: MOOR
divisions: UCL
divisions: B02
divisions: C07
divisions: D08
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: PURPOSE: To compare routine clinical examination with optical coherence tomography angiography (OCTA) for the assessment of limbal conjunctival ischemia following a chemical burn. SETTING: Validity analysis. METHODS: We assessed ten participants (15 eyes) with an acute chemical injury. Clinical photographs were used to determine the extent of any limbal conjunctival epithelial defect and ischemia. These were compared with the extent of limbal ischemia identified on OCTA images of the ocular surface. Quantitative and longitudinal analysis using the OCTA software were also performed. Correlations with visual outcome were sought using clinical and OCTA-derived variables. RESULTS: The extent of clinically determined limbal ischemia was less than that identified with OCTA (2.3±3.6 clock hours v 5.1±4.2 clock hours, p = 0.003), which in turn was less than the size of limbal conjunctival epithelial defect (7.3±5.1 clock hours, p = 0.03). Longitudinal OCTA analysis showed that mean vessel area increased by 0.2 ±0.1% during the study, corresponding to a rate of vascular recovery of 0.9mm^{2}/day. Significant correlations were found between visual outcome at 3 months and limbal conjunctival fluorescein staining (r = 0.67, p = 0.006), and limbal conjunctival ischemia on OCTA (r = 0.76, p = 0.001). CONCLUSIONS: OCTA can objectively identify and monitor the recovery of limbal ischemia following an acute ocular chemical injury. OCTA confirms that limbal ischemia is usually more extensive than is suggested by clinical examination, and the former is highly correlated with visual outcome. OCTA therefore is a useful tool in the management of ocular chemical injury.
date: 2019-09
date_type: published
official_url: https://doi.org/10.1016/j.ajo.2019.04.021
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1657714
doi: 10.1016/j.ajo.2019.04.021
pii: S0002-9394(19)30202-8
lyricists_name: Keane, Pearse
lyricists_name: Sim, Dawn
lyricists_name: Tuft, Stephen
lyricists_name: Wilkins, Mark
lyricists_id: KPEAR28
lyricists_id: DASYS88
lyricists_id: SJTUF57
lyricists_id: MRWIL52
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: American Journal of Ophthalmology
volume: 205
pagerange: 165-174
event_location: United States
issn: 1879-1891
citation:        Fung, SSM;    Stewart, RMK;    Dhallu, SK;    Sim, DA;    Keane, PA;    Wilkins, MR;    Tuft, SJ;      (2019)    Anterior Segment Optical Coherence Tomographic Angiography Assessment of Acute Chemical Injury.                   American Journal of Ophthalmology , 205    pp. 165-174.    10.1016/j.ajo.2019.04.021 <https://doi.org/10.1016/j.ajo.2019.04.021>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10074494/7/Keane_Anterior%20segment%20optical%20coherence%20tomographic%20angiography%20assessment%20of%20acute%20chemical%20injury_AAM.pdf