eprintid: 10074393 rev_number: 30 eprint_status: archive userid: 608 dir: disk0/10/07/43/93 datestamp: 2019-10-03 10:27:19 lastmod: 2021-09-19 22:56:51 status_changed: 2019-10-04 09:45:23 type: proceedings_section metadata_visibility: show creators_name: Palombo, M creators_name: Nunes, D creators_name: Alexander, D creators_name: Zhang, H creators_name: Shemesh, N title: Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F48 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Biophysical modelling of diffusion-weighted MRI (DW-MRI) data can help to gain more insight into brain microstructure. However, models need to be validated. This work validates a recently-developed technique for non-invasive mapping of brain cell-body (soma) size/ density with DW-MRI, by using ultrahigh-field DW-MRI experiments and histology of mouse brain. Predictions from numerical simulations are experimentally confirmed and brain’s maps of MR-measured soma size/density are shown to correspond very well with histology. We provide differential contrasts between cell layers that are less expressed in tensor analyses, leading to novel complementary contrasts of the brain tissue. Limitations and future research directions are discussed. date: 2019-05-11 date_type: published publisher: ISMRM (International Society for Magnetic Resonance in Medicine) official_url: https://www.ismrm.org/19m/ oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1658746 lyricists_name: Alexander, Daniel lyricists_name: Palombo, Marco lyricists_name: Zhang, Hui lyricists_id: DALEX06 lyricists_id: MPALO05 lyricists_id: HZHAN50 actors_name: Palombo, Marco actors_id: MPALO05 actors_role: owner full_text_status: public series: ISMRM (International Society for Magnetic Resonance in Medicine) volume: 27 place_of_pub: Concord, CA, USA event_title: ISMRM 27th Annual Meeting and Exhibition, 11-16 May 2019, Montreal, QC, Canada institution: ISMRM 27th Annual Meeting & Exhibition book_title: Proceedings of the 27th ISMRM Annual Meeting and Exhibition editors_name: Port, JD editors_name: Noll, DC citation: Palombo, M; Nunes, D; Alexander, D; Zhang, H; Shemesh, N; (2019) Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field. In: Port, JD and Noll, DC, (eds.) Proceedings of the 27th ISMRM Annual Meeting and Exhibition. ISMRM (International Society for Magnetic Resonance in Medicine): Concord, CA, USA. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10074393/1/Abstract_1_Palombo.pdf