TY  - GEN
CY  - Concord, CA, USA
A1  - Palombo, M
A1  - Nunes, D
A1  - Alexander, D
A1  - Zhang, H
A1  - Shemesh, N
T3  - ISMRM (International Society for Magnetic Resonance in Medicine)
ID  - discovery10074393
N2  - Biophysical modelling of diffusion-weighted MRI (DW-MRI) data can help to gain more insight into brain microstructure. However, models need to be validated. This work validates a recently-developed technique for non-invasive mapping of brain cell-body (soma) size/ density with DW-MRI, by using ultrahigh-field DW-MRI experiments and histology of mouse brain. Predictions from numerical simulations are experimentally confirmed and brain?s maps of MR-measured soma size/density are shown to correspond very well with histology. We provide differential contrasts between cell layers that are less expressed in tensor analyses, leading to novel complementary contrasts of the brain tissue. Limitations and future research directions are discussed.
PB  - ISMRM (International Society for Magnetic Resonance in Medicine)
UR  - https://www.ismrm.org/19m/
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
TI  - Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field
Y1  - 2019/05/11/
AV  - public
ER  -