?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Histological+validation+of+the+brain+cell+body+imaging+with+diffusion+MRI+at+ultrahigh+field&rft.creator=Palombo%2C+M&rft.creator=Nunes%2C+D&rft.creator=Alexander%2C+D&rft.creator=Zhang%2C+H&rft.creator=Shemesh%2C+N&rft.description=Biophysical+modelling+of+diffusion-weighted+MRI+(DW-MRI)+data+can+help+to+gain+more+insight+into+brain+microstructure.+However%2C+models+need+to+be+validated.+This+work+validates+a+recently-developed+technique+for+non-invasive+mapping+of+brain+cell-body+(soma)+size%2F+density+with+DW-MRI%2C+by+using+ultrahigh-field+DW-MRI+experiments+and+histology+of+mouse+brain.+Predictions+from+numerical+simulations+are+experimentally+confirmed+and+brain%E2%80%99s+maps+of+MR-measured+soma+size%2Fdensity+are+shown+to+correspond+very+well+with+histology.+We+provide+differential+contrasts+between+cell+layers+that+are+less+expressed+in+tensor+analyses%2C+leading+to+novel+complementary+contrasts+of+the+brain+tissue.+Limitations+and+future+research+directions+are+discussed.&rft.publisher=ISMRM+(International+Society+for+Magnetic+Resonance+in+Medicine)&rft.contributor=Port%2C+JD&rft.contributor=Noll%2C+DC&rft.date=2019-05-11&rft.type=Proceedings+paper&rft.publisher=ISMRM+27th+Annual+Meeting+%26+Exhibition&rft.language=eng&rft.source=+++++In%3A+Port%2C+JD+and+Noll%2C+DC%2C+(eds.)+Proceedings+of+the+27th+ISMRM+Annual+Meeting+and+Exhibition.++++ISMRM+(International+Society+for+Magnetic+Resonance+in+Medicine)%3A+Concord%2C+CA%2C+USA.+(2019)+++++&rft.format=text&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10074393%2F1%2FAbstract_1_Palombo.pdf&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10074393%2F&rft.rights=open