eprintid: 10073873
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/07/38/73
datestamp: 2019-05-15 16:01:01
lastmod: 2021-09-20 00:33:28
status_changed: 2019-05-15 16:01:01
type: article
metadata_visibility: show
creators_name: Khedr, EM
creators_name: Al-Fawal, B
creators_name: Wraith, AA
creators_name: Saber, M
creators_name: Hasan, AM
creators_name: Bassiony, A
creators_name: Eldein, AN
creators_name: Rothwell, JC
title: The Effect of 20 Hz versus 1 Hz Repetitive Transcranial Magnetic Stimulation on Motor Dysfunction in Parkinson’s Disease: Which Is More Beneficial?
ispublished: inpress
subjects: UCH
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: There is evidence that both high and low frequency rTMS may have therapeutic effects on motor performance of Parkinson's disease. OBJECTIVE: The aim of the study was to conduct the first direct comparison of the two approaches. METHODS: 52 PD patients were randomly classified into two groups. The first group received 20 Hz and the 2nd group received 1 Hz rTMS with a total of 2000 pulses over M1of each hemisphere for ten days. Effects were assessed with the Unified Parkinson's Disease Rating Scale part III (UPDRS), Instrumental Activity of Daily Living (IADL), and a self-assessment score (SA) before, after the last session, and one month later. Cortical excitability was measured before and after the end of sessions. RESULTS: There was a significant improvement on all rating scales after either 1 Hz or 20 Hz rTMS, but the effect persisted for longer after 20 Hz (treatment X time interaction for UPDRS and IADL (P = 0.075 and 0.04, respectively). Neither treatment affected motor thresholds, but 20 Hz rTMS increased MEP amplitude and the duration of transcallosal inhibition. In an exploratory analysis, each group was subdivided into akinetic-rigid and tremor dominant subgroups and the effects of 1 Hz and 20 Hz treatment recalculated. There was weak evidence that patients with an akinetic-rigid presentation may respond better than those with predominant tremor. CONCLUSION: Both 20 Hz and 1 Hz rTMS improve motor function in PD, but 20 Hz rTMS is more effective.
date: 2019-03-21
date_type: published
official_url: http://doi.org/10.3233/JPD-181540
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1644155
doi: 10.3233/JPD-181540
pii: JPD181540
language_elements: English
lyricists_name: Rothwell, John
lyricists_id: JCROT52
actors_name: Rothwell, John
actors_id: JCROT52
actors_role: owner
full_text_status: public
publication: Journal of Parkinson's Disease
event_location: Netherlands
issn: 1877-718X
citation:        Khedr, EM;    Al-Fawal, B;    Wraith, AA;    Saber, M;    Hasan, AM;    Bassiony, A;    Eldein, AN;           Khedr, EM;  Al-Fawal, B;  Wraith, AA;  Saber, M;  Hasan, AM;  Bassiony, A;  Eldein, AN;  Rothwell, JC;   - view fewer <#>    (2019)    The Effect of 20 Hz versus 1 Hz Repetitive Transcranial Magnetic Stimulation on Motor Dysfunction in Parkinson’s Disease: Which Is More Beneficial?                   Journal of Parkinson's Disease        10.3233/JPD-181540 <https://doi.org/10.3233/JPD-181540>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10073873/3/Rothwell_The%20Effect%20of%2020%20Hz%20versus%201%20Hz%20Repetitive%20Transcranial%20Magnetic%20Stimulation%20on%20Motor%20Dysfunction%20in%20Parkinson%E2%80%99s%20Disease_AAM.pdf