TY  - JOUR
TI  - Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome
AV  - public
VL  - 5
Y1  - 2019/04/24/
N1  - This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
IS  - 1
ID  - discovery10073783
N2  - Objectives?To report on fatigue in patients from the
United Kingdom primary Sjögren?s syndrome (pSS) registry
identifying factors associated with fatigue and robust to
assignable causes such as comorbidities and medications
associated with drowsiness.
Methods From our cohort (n = 608), we identified those
with comorbidities associated with fatigue, and those
taking medications associated with drowsiness. We
constructed dummy variables, permitting the contribution
of these potentially assignable causes of fatigue to be
assessed. Using multiple regression analysis, we modelled
the relationship between Profile of Fatigue and Discomfort
physical and mental fatigue scores and potentially related
variables.
Results Pain, depression and daytime sleepiness
scores were closely associated with both physical and
mental fatigue (all p ? 0.0001). In addition, dryness was
strongly associated with physical fatigue (p ? 0.0001).
These effects were observed even after adjustment for
comorbidities associated with fatigue or medications
associated with drowsiness.
Conclusions?These findings support further research and
clinical interventions targeting pain, dryness, depression
and sleep to improve fatigue in patients with pSS.
This finding is robust to both the effect of other
comorbidities associated with fatigue and medications
associated with drowsiness
SN  - 2056-5933
UR  - https://doi.org/10.1136/rmdopen-2018-000885
JF  - RMD Open
A1  - Hackett, KL
A1  - Davies, K
A1  - Tarn, J
A1  - Bragg, R
A1  - Hargreaves, B
A1  - Miyamoto, S
A1  - McMeekin, P
A1  - Mitchell, S
A1  - Bowman, S
A1  - Price, EJ
A1  - Pease, C
A1  - Emery, P
A1  - Andrews, J
A1  - Lanyon, P
A1  - Hunter, J
A1  - Gupta, M
A1  - Bombardieri, M
A1  - Sutcliffe, N
A1  - Pitzalis, C
A1  - McLaren, J
A1  - Cooper, A
A1  - Regan, M
A1  - Giles, I
A1  - Isenberg, D
A1  - Vadivelu, S
A1  - Coady, D
A1  - Dasgupta, B
A1  - McHugh, N
A1  - Young-Min, S
A1  - Moots, R
A1  - Gendi, N
A1  - Akil, M
A1  - Griffiths, B
A1  - Lendrem, DW
A1  - Ng, WF
ER  -