%0 Journal Article
%@ 2056-5933
%A Hackett, KL
%A Davies, K
%A Tarn, J
%A Bragg, R
%A Hargreaves, B
%A Miyamoto, S
%A McMeekin, P
%A Mitchell, S
%A Bowman, S
%A Price, EJ
%A Pease, C
%A Emery, P
%A Andrews, J
%A Lanyon, P
%A Hunter, J
%A Gupta, M
%A Bombardieri, M
%A Sutcliffe, N
%A Pitzalis, C
%A McLaren, J
%A Cooper, A
%A Regan, M
%A Giles, I
%A Isenberg, D
%A Vadivelu, S
%A Coady, D
%A Dasgupta, B
%A McHugh, N
%A Young-Min, S
%A Moots, R
%A Gendi, N
%A Akil, M
%A Griffiths, B
%A Lendrem, DW
%A Ng, WF
%D 2019
%F discovery:10073783
%J RMD Open
%N 1
%T Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome
%U https://discovery.ucl.ac.uk/id/eprint/10073783/
%V 5
%X Objectives To report on fatigue in patients from the  United Kingdom primary Sjögren’s syndrome (pSS) registry  identifying factors associated with fatigue and robust to  assignable causes such as comorbidities and medications  associated with drowsiness.  Methods From our cohort (n = 608), we identified those  with comorbidities associated with fatigue, and those  taking medications associated with drowsiness. We  constructed dummy variables, permitting the contribution  of these potentially assignable causes of fatigue to be  assessed. Using multiple regression analysis, we modelled  the relationship between Profile of Fatigue and Discomfort  physical and mental fatigue scores and potentially related  variables.  Results Pain, depression and daytime sleepiness  scores were closely associated with both physical and  mental fatigue (all p ≤ 0.0001). In addition, dryness was  strongly associated with physical fatigue (p ≤ 0.0001).  These effects were observed even after adjustment for  comorbidities associated with fatigue or medications  associated with drowsiness.  Conclusions These findings support further research and  clinical interventions targeting pain, dryness, depression  and sleep to improve fatigue in patients with pSS.  This finding is robust to both the effect of other  comorbidities associated with fatigue and medications  associated with drowsiness
%Z This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.