eprintid: 10073690 rev_number: 30 eprint_status: archive userid: 608 dir: disk0/10/07/36/90 datestamp: 2019-05-15 16:24:51 lastmod: 2021-12-01 23:30:23 status_changed: 2019-05-15 16:24:51 type: article metadata_visibility: show creators_name: Little, D creators_name: Ketteler, R creators_name: Gissen, P creators_name: Devine, MJ title: Using stem cell-derived neurons in drug screening for neurological diseases ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 divisions: C08 divisions: D77 divisions: D13 divisions: G23 keywords: Alzheimer's disease, Drug discovery, Drug screening, Embryonic stem cells, High content screening, Huntington's disease, Induced pluripotent stem cells, Motor neuron disease, Neurodegeneration, Parkinson's disease note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Induced pluripotent stem cells and their derivatives have become an important tool for researching disease mechanisms. It is hoped that they could be used to discover new therapies by providing the most reliable and relevant human in vitro disease models for drug discovery. This review will summarize recent efforts to use stem cell-derived neurons for drug screening. We also explain the current hurdles to using these cells for high-throughput pharmaceutical screening and developments that may help overcome these hurdles. Finally, we critically discuss whether induced pluripotent stem cell-derived neurons will come to fruition as a model that is regularly used to screen for drugs to treat neurological diseases. date: 2019-06 date_type: published official_url: https://doi.org/10.1016/j.neurobiolaging.2019.02.008 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1645166 doi: 10.1016/j.neurobiolaging.2019.02.008 pii: S0197-4580(19)30055-7 lyricists_name: Devine, Michael lyricists_name: Gissen, Paul lyricists_name: Ketteler, Robin lyricists_name: Little, Daniel lyricists_id: MJDEV09 lyricists_id: PGISS10 lyricists_id: RKETT46 lyricists_id: DLITT46 actors_name: Gissen, Paul actors_id: PGISS10 actors_role: owner full_text_status: public publication: Neurobiology of Aging volume: 78 pagerange: 130-141 issn: 0197-4580 citation: Little, D; Ketteler, R; Gissen, P; Devine, MJ; (2019) Using stem cell-derived neurons in drug screening for neurological diseases. Neurobiology of Aging , 78 pp. 130-141. 10.1016/j.neurobiolaging.2019.02.008 <https://doi.org/10.1016/j.neurobiolaging.2019.02.008>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10073690/3/Gissen_NoA%20Review%20Manuscript%20Dec%202018%20DL%20Changes%20Highlighted_MJD_DL%20%281%29.pdf