%J Neurobiology of Aging
%K Alzheimer's disease, Drug discovery, Drug screening, Embryonic stem cells, High content screening, Huntington's disease, Induced pluripotent stem cells, Motor neuron disease, Neurodegeneration, Parkinson's disease
%A D Little
%A R Ketteler
%A P Gissen
%A MJ Devine
%V 78
%X Induced pluripotent stem cells and their derivatives have become an important tool for researching disease mechanisms. It is hoped that they could be used to discover new therapies by providing the most reliable and relevant human in vitro disease models for drug discovery. This review will summarize recent efforts to use stem cell-derived neurons for drug screening. We also explain the current hurdles to using these cells for high-throughput pharmaceutical screening and developments that may help overcome these hurdles. Finally, we critically discuss whether induced pluripotent stem cell-derived neurons will come to fruition as a model that is regularly used to screen for drugs to treat neurological diseases.
%O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
%T Using stem cell-derived neurons in drug screening for neurological diseases
%P 130-141
%L discovery10073690
%D 2019