TY  - JOUR
N2  - Induced pluripotent stem cells and their derivatives have become an important tool for researching disease mechanisms. It is hoped that they could be used to discover new therapies by providing the most reliable and relevant human in vitro disease models for drug discovery. This review will summarize recent efforts to use stem cell-derived neurons for drug screening. We also explain the current hurdles to using these cells for high-throughput pharmaceutical screening and developments that may help overcome these hurdles. Finally, we critically discuss whether induced pluripotent stem cell-derived neurons will come to fruition as a model that is regularly used to screen for drugs to treat neurological diseases.
VL  - 78
Y1  - 2019/06//
A1  - Little, D
A1  - Ketteler, R
A1  - Gissen, P
A1  - Devine, MJ
ID  - discovery10073690
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
SN  - 0197-4580
EP  - 141
JF  - Neurobiology of Aging
AV  - public
SP  - 130
UR  - https://doi.org/10.1016/j.neurobiolaging.2019.02.008
TI  - Using stem cell-derived neurons in drug screening for neurological diseases
KW  - Alzheimer's disease
KW  -  Drug discovery
KW  -  Drug screening
KW  -  Embryonic stem cells
KW  -  High content screening
KW  -  Huntington's disease
KW  -  Induced pluripotent stem cells
KW  -  Motor neuron disease
KW  -  Neurodegeneration
KW  -  Parkinson's disease
ER  -