<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10073276> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/title> "Enrichment of clinical trials in MCI due to AD using markers of amyloid and neurodegeneration"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/abstract> "OBJECTIVE: To investigate the effect of enriching mild cognitive impairment (MCI) clinical trials using combined markers of amyloid pathology and neurodegeneration. METHODS: We evaluate an implementation of the recent National Institute for Aging-Alzheimer's Association (NIA-AA) diagnostic criteria for MCI due to Alzheimer disease (AD) as inclusion criteria in clinical trials and assess the effect of enrichment with amyloid (A+), neurodegeneration (N+), and their combination (A+N+) on the rate of clinical progression, required sample sizes, and estimates of trial time and cost. RESULTS: Enrichment based on an individual marker (A+ or N+) substantially improves all assessed trial characteristics. Combined enrichment (A+N+) further improves these results with a reduction in required sample sizes by 45% to 60%, depending on the endpoint. CONCLUSIONS: Operationalizing the NIA-AA diagnostic criteria for clinical trial screening has the potential to substantially improve the statistical power of trials in MCI due to AD by identifying a more rapidly progressing patient population."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/date> "2016-09-20" . <https://discovery.ucl.ac.uk/id/document/893032> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/volume> "87" . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/issue> "12" . <https://discovery.ucl.ac.uk/id/publication/ext-1526632X> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-1526632X> <http://xmlns.com/foaf/0.1/name> "Neurology"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-1526632X> . <https://discovery.ucl.ac.uk/id/publication/ext-1526632X> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:1526632X> . <https://discovery.ucl.ac.uk/id/publication/ext-1526632X> <http://purl.org/ontology/bibo/issn> "1526632X" . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c7aea27bbcb1b242456f0d4060e5a7c3> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> . <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-c7aea27bbcb1b242456f0d4060e5a7c3> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-37e0dd10814f991b3ee013a1fd0cc742> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> . <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-37e0dd10814f991b3ee013a1fd0cc742> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e53bf6654fe1ffc27957c31c66e224b6> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> . <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-e53bf6654fe1ffc27957c31c66e224b6> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7bad7678767c9a1ce0a3a94d302b7afa> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> . <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-7bad7678767c9a1ce0a3a94d302b7afa> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dc340c4df7b2e40bfa57519e2d5b9dd6> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> . <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-dc340c4df7b2e40bfa57519e2d5b9dd6> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0bc9fafe2821b7a446eac4f28086a7ac> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> . <https://discovery.ucl.ac.uk/id/eprint/10073276#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-0bc9fafe2821b7a446eac4f28086a7ac> . <https://discovery.ucl.ac.uk/id/person/ext-dc340c4df7b2e40bfa57519e2d5b9dd6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-dc340c4df7b2e40bfa57519e2d5b9dd6> <http://xmlns.com/foaf/0.1/givenName> "DLG"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-dc340c4df7b2e40bfa57519e2d5b9dd6> <http://xmlns.com/foaf/0.1/familyName> "Hill"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-dc340c4df7b2e40bfa57519e2d5b9dd6> <http://xmlns.com/foaf/0.1/name> "DLG Hill"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0bc9fafe2821b7a446eac4f28086a7ac> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0bc9fafe2821b7a446eac4f28086a7ac> <http://xmlns.com/foaf/0.1/givenName> ""^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0bc9fafe2821b7a446eac4f28086a7ac> <http://xmlns.com/foaf/0.1/familyName> "Alzheimer's Disease Neuroimaging Initiative"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0bc9fafe2821b7a446eac4f28086a7ac> <http://xmlns.com/foaf/0.1/name> " Alzheimer's Disease Neuroimaging Initiative"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e53bf6654fe1ffc27957c31c66e224b6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e53bf6654fe1ffc27957c31c66e224b6> <http://xmlns.com/foaf/0.1/givenName> "KR"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e53bf6654fe1ffc27957c31c66e224b6> <http://xmlns.com/foaf/0.1/familyName> "Gray"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e53bf6654fe1ffc27957c31c66e224b6> <http://xmlns.com/foaf/0.1/name> "KR Gray"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-37e0dd10814f991b3ee013a1fd0cc742> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-37e0dd10814f991b3ee013a1fd0cc742> <http://xmlns.com/foaf/0.1/givenName> "AJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-37e0dd10814f991b3ee013a1fd0cc742> <http://xmlns.com/foaf/0.1/familyName> "Schwarz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-37e0dd10814f991b3ee013a1fd0cc742> <http://xmlns.com/foaf/0.1/name> "AJ Schwarz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7bad7678767c9a1ce0a3a94d302b7afa> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7bad7678767c9a1ce0a3a94d302b7afa> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7bad7678767c9a1ce0a3a94d302b7afa> <http://xmlns.com/foaf/0.1/familyName> "Yu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7bad7678767c9a1ce0a3a94d302b7afa> <http://xmlns.com/foaf/0.1/name> "P Yu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c7aea27bbcb1b242456f0d4060e5a7c3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c7aea27bbcb1b242456f0d4060e5a7c3> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c7aea27bbcb1b242456f0d4060e5a7c3> <http://xmlns.com/foaf/0.1/familyName> "Wolz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c7aea27bbcb1b242456f0d4060e5a7c3> <http://xmlns.com/foaf/0.1/name> "R Wolz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10073276> 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<https://discovery.ucl.ac.uk/id/document/893033> . <https://discovery.ucl.ac.uk/id/document/893033> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/893033> <http://www.w3.org/2000/01/rdf-schema#label> "Enrichment of clinical trials in MCI due to AD using markers of amyloid and neurodegeneration (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/893033> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/893032> . <https://discovery.ucl.ac.uk/id/document/893033> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/893032> . <https://discovery.ucl.ac.uk/id/document/893033> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/893032> . <https://discovery.ucl.ac.uk/id/eprint/10073276> <http://eprints.org/ontology/hasDocument> 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