eprintid: 10072335
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/07/23/35
datestamp: 2019-04-16 14:15:44
lastmod: 2021-12-13 23:56:35
status_changed: 2019-04-16 14:15:44
type: article
metadata_visibility: show
creators_name: Turkova, A
creators_name: Volynets, GV
creators_name: Crichton, S
creators_name: Skvortsova, TA
creators_name: Panfilova, VN
creators_name: Rogozina, NV
creators_name: Khavkin, AI
creators_name: Tumanova, EL
creators_name: Indolfi, G
creators_name: Thorne, C
title: Advanced liver disease in Russian children and adolescents with chronic hepatitis C
ispublished: pub
subjects: GOSH
divisions: UCL
divisions: B02
divisions: D65
divisions: J38
divisions: D13
divisions: G25
keywords: Russia, adolescent, biopsy, child, chronic hepatitis C, elastography, liver fibrosis
note: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction
in any medium, provided the original work is properly cited and is not used for commercial purposes. For more info see: https://creativecommons.org/licenses/by-nc/4.0/deed.en
abstract: Russia has one of the highest prevalences of paediatric chronic hepatitis C infection (CHC). Our aim was to provide a detailed characterization of children and adolescents with CHC including treatment outcomes.Thus, an observational study of children with CHC aged <18 years was conducted in three hepatology centres from November 2014 to May 2017. Of 301 children(52% male), 196(65%) acquired HCV vertically, 70(23%) had a history of blood transfusion or invasive procedures, 1 injecting drug use and 34(11%) had no known risk factors. Median age at HCV diagnosis was 3.1[IQR 1.1,8.2] and 10.8[7.4,14.7] at last follow-up. The most common genotype was 1b(51%), followed by 3(31%). Over a quarter of patients (84,28%) had raised liver transaminases. Of 92 with liver biopsy, 38(41%) had bridging fibrosis (median age 10.4[7.1,14.1]). Of 223 evaluated by transient elastography (TE), 67(30%) had liver stiffness ≥5.0kPa. For each year increase in age mean stiffness increased by 0.09kPa(95%CI 0.05,0.13, p<0.001). There was significant correlation between liver stiffness and biopsy results (Tau-b=0.29, p=0.042). Of 205 treated with IFN-based regimens, 100(49%) had SVR24. Most children (191,93%) experienced adverse reactions, leading to treatment discontinuation in 6(3%). In conclusion, a third of children acquired HCV via non-vertical routes and a substantial proportion of those with liver biopsy had advanced liver disease. Only half of children achieved SVR24 with IFN-based regimens highlighting the need for more effective and better tolerated treatments with direct-acting antivirals. Further studies are warranted in Russia on causes and prevention of non-vertical transmission of HCV in children. This article is protected by copyright. All rights reserved.
date: 2019-07
date_type: published
official_url: https://doi.org/10.1111/jvh.13093
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1638098
doi: 10.1111/jvh.13093
lyricists_name: Crichton, Siobhan
lyricists_name: Thorne, Claire
lyricists_name: Turkova, Anna
lyricists_id: SCRIC86
lyricists_id: CNTHO93
lyricists_id: ATURK51
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: Journal of Viral Hepatitis
volume: 26
number: 7
pagerange: 881-892
event_location: England
issn: 1365-2893
citation:        Turkova, A;    Volynets, GV;    Crichton, S;    Skvortsova, TA;    Panfilova, VN;    Rogozina, NV;    Khavkin, AI;             ... Thorne, C; + view all <#>        Turkova, A;  Volynets, GV;  Crichton, S;  Skvortsova, TA;  Panfilova, VN;  Rogozina, NV;  Khavkin, AI;  Tumanova, EL;  Indolfi, G;  Thorne, C;   - view fewer <#>    (2019)    Advanced liver disease in Russian children and adolescents with chronic hepatitis C.                   Journal of Viral Hepatitis , 26  (7)   pp. 881-892.    10.1111/jvh.13093 <https://doi.org/10.1111/jvh.13093>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10072335/1/Turkova_et_al-2019-Journal_of_Viral_Hepatitis.pdf