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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/title> "Meso scale discovery-based assays for the detection of aggregated huntingtin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/abstract> "Huntington’s disease (HD) is a monogenic neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin (HTT) gene, leading to an expanded poly-glutamine (polyQ) stretch in the HTT protein. This mutant HTT (mHTT) protein is highly prone to intracellular aggregation, causing significant damage and cellular loss in the striatal, cortical, and other regions of the brain. Therefore, modulation of mHTT levels in these brain regions in order to reduce intracellular mHTT and aggregate levels represents a direct approach in the development of HD therapeutics. To this end, assays that can be used to detect changes in HTT levels in biological samples are invaluable tools to assess target engagement and guide dose selection in clinical trials. The Meso Scale Discovery (MSD) ELISA-based assay platform is a robust and sensitive method previously employed for the quantification of HTT. However, the currently available MSD assays for HTT are primarily detecting the monomeric soluble form of the protein, but not aggregated species. In this study, we describe the development of novel MSD assays preferentially detecting mHTT in an aggregated form. Recombinant monomeric HTT(1–97)-Q46, which forms aggregates in a time-dependent manner, was used to characterize the ability of each established assay to distinguish between HTT monomers and HTT in a higher assembly state. Further validation of these assays was performed using brain lysates from R6/2, zQ175 knock-in, and BACHD mouse models, to replicate a previously well-characterized age-dependent increase in brain aggregate signals, as well as a significant reduction of aggregate levels in the striatum following mHTT knockdown with a CAG-directed allele-specific zinc-finger repressor protein (ZFP). Lastly, size exclusion chromatography was used to separate and characterize HTT species from brain tissue lysates to demonstrate specificity of the assays for the fractions containing aggregated HTT. In summary, we demonstrate that the newly developed assays preferentially detect aggregated HTT with improved performance in comparison to previous assay technologies. These assays complement the existing MSD platform assays specific for soluble HTT monomers, allowing for a more comprehensive analysis of disease-relevant HTT species in preclinical models of HD."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/date> "2019-03-26" .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b9914bbc08372b783f79ed67bc6bd08a> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c80b975c9efd818a00d2bf44dfce50c7> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-99e7ec24edba8a343f93267080fb4a44> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-99e7ec24edba8a343f93267080fb4a44> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-892a56ad9f4309e65b1ae36b42aa0fea> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-892a56ad9f4309e65b1ae36b42aa0fea> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a1fa4933374353cd8a1ae5c80e422b4d> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-a1fa4933374353cd8a1ae5c80e422b4d> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a1254585c03cff85485e7392959eaf20> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a1254585c03cff85485e7392959eaf20> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-32f8739101cee82c2eedb7a8e884fb83> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-32f8739101cee82c2eedb7a8e884fb83> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4b4e45e41f5031a6e33e489ba2c590fc> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-4b4e45e41f5031a6e33e489ba2c590fc> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-daf3490de64e57ade1a7a8510f8f4668> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-daf3490de64e57ade1a7a8510f8f4668> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3923b0223de2526186fe77d50ae8eea6> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-3923b0223de2526186fe77d50ae8eea6> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4cf2d896815600607837f037a9ac1c4b> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-4cf2d896815600607837f037a9ac1c4b> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0858a564342bf048a1db2ff932f2254a> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-0858a564342bf048a1db2ff932f2254a> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3586da7354a132d4bd9cc20370f31072> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-3586da7354a132d4bd9cc20370f31072> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-998a87078986b4415705e83d860c16de> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1a571decd5cd5d5f81a490f97561329b> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_20> <https://discovery.ucl.ac.uk/id/person/ext-1a571decd5cd5d5f81a490f97561329b> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-43559b97e3d8d10568f37915f0a59c76> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4144c2bc6e501b6cc9ec8f52f2ded62a> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10072163#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10072163#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_22> <https://discovery.ucl.ac.uk/id/person/ext-4144c2bc6e501b6cc9ec8f52f2ded62a> .
<https://discovery.ucl.ac.uk/id/person/ext-99e7ec24edba8a343f93267080fb4a44> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-99e7ec24edba8a343f93267080fb4a44> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-99e7ec24edba8a343f93267080fb4a44> <http://xmlns.com/foaf/0.1/familyName> "Kleinschmidt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-99e7ec24edba8a343f93267080fb4a44> <http://xmlns.com/foaf/0.1/name> "M Kleinschmidt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b9914bbc08372b783f79ed67bc6bd08a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b9914bbc08372b783f79ed67bc6bd08a> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b9914bbc08372b783f79ed67bc6bd08a> <http://xmlns.com/foaf/0.1/familyName> "Janack"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b9914bbc08372b783f79ed67bc6bd08a> <http://xmlns.com/foaf/0.1/name> "I Janack"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9c83d6b9edfa52a05c3a23a9f6157894> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9c83d6b9edfa52a05c3a23a9f6157894> <http://xmlns.com/foaf/0.1/givenName> "W"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9c83d6b9edfa52a05c3a23a9f6157894> <http://xmlns.com/foaf/0.1/familyName> "Reindl"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9c83d6b9edfa52a05c3a23a9f6157894> <http://xmlns.com/foaf/0.1/name> "W Reindl"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ac3dcace91db58d3c4bccb65503ba88b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ac3dcace91db58d3c4bccb65503ba88b> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ac3dcace91db58d3c4bccb65503ba88b> <http://xmlns.com/foaf/0.1/familyName> "Zerbinatti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ac3dcace91db58d3c4bccb65503ba88b> <http://xmlns.com/foaf/0.1/name> "C Zerbinatti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-892a56ad9f4309e65b1ae36b42aa0fea> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-892a56ad9f4309e65b1ae36b42aa0fea> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-892a56ad9f4309e65b1ae36b42aa0fea> <http://xmlns.com/foaf/0.1/familyName> "Sedaghat"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-892a56ad9f4309e65b1ae36b42aa0fea> <http://xmlns.com/foaf/0.1/name> "Y Sedaghat"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998a87078986b4415705e83d860c16de> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-998a87078986b4415705e83d860c16de> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998a87078986b4415705e83d860c16de> <http://xmlns.com/foaf/0.1/familyName> "Weiss"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-998a87078986b4415705e83d860c16de> <http://xmlns.com/foaf/0.1/name> "A Weiss"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c80b975c9efd818a00d2bf44dfce50c7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c80b975c9efd818a00d2bf44dfce50c7> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c80b975c9efd818a00d2bf44dfce50c7> <http://xmlns.com/foaf/0.1/familyName> "Lindner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c80b975c9efd818a00d2bf44dfce50c7> <http://xmlns.com/foaf/0.1/name> "I Lindner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43559b97e3d8d10568f37915f0a59c76> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-43559b97e3d8d10568f37915f0a59c76> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43559b97e3d8d10568f37915f0a59c76> <http://xmlns.com/foaf/0.1/familyName> "Munoz-Sanjuan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43559b97e3d8d10568f37915f0a59c76> <http://xmlns.com/foaf/0.1/name> "I Munoz-Sanjuan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1254585c03cff85485e7392959eaf20> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a1254585c03cff85485e7392959eaf20> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1254585c03cff85485e7392959eaf20> <http://xmlns.com/foaf/0.1/familyName> "Tillack"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1254585c03cff85485e7392959eaf20> <http://xmlns.com/foaf/0.1/name> "K Tillack"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32f8739101cee82c2eedb7a8e884fb83> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-32f8739101cee82c2eedb7a8e884fb83> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32f8739101cee82c2eedb7a8e884fb83> <http://xmlns.com/foaf/0.1/familyName> "Schmidt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32f8739101cee82c2eedb7a8e884fb83> <http://xmlns.com/foaf/0.1/name> "C Schmidt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0858a564342bf048a1db2ff932f2254a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0858a564342bf048a1db2ff932f2254a> <http://xmlns.com/foaf/0.1/givenName> "GF"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0858a564342bf048a1db2ff932f2254a> <http://xmlns.com/foaf/0.1/familyName> "Osborne"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0858a564342bf048a1db2ff932f2254a> <http://xmlns.com/foaf/0.1/name> "GF Osborne"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7accf979618d6314c4bb3d5228bca148> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7accf979618d6314c4bb3d5228bca148> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7accf979618d6314c4bb3d5228bca148> <http://xmlns.com/foaf/0.1/familyName> "Baldo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7accf979618d6314c4bb3d5228bca148> <http://xmlns.com/foaf/0.1/name> "B Baldo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1a571decd5cd5d5f81a490f97561329b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1a571decd5cd5d5f81a490f97561329b> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1a571decd5cd5d5f81a490f97561329b> <http://xmlns.com/foaf/0.1/familyName> "Bard"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1a571decd5cd5d5f81a490f97561329b> <http://xmlns.com/foaf/0.1/name> "J Bard"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4144c2bc6e501b6cc9ec8f52f2ded62a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4144c2bc6e501b6cc9ec8f52f2ded62a> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4144c2bc6e501b6cc9ec8f52f2ded62a> <http://xmlns.com/foaf/0.1/familyName> "Macdonald"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4144c2bc6e501b6cc9ec8f52f2ded62a> <http://xmlns.com/foaf/0.1/name> "D Macdonald"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ae211a4e4162075a252137811d5b6d1c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ae211a4e4162075a252137811d5b6d1c> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ae211a4e4162075a252137811d5b6d1c> <http://xmlns.com/foaf/0.1/familyName> "Schulz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ae211a4e4162075a252137811d5b6d1c> <http://xmlns.com/foaf/0.1/name> "J Schulz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3586da7354a132d4bd9cc20370f31072> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3586da7354a132d4bd9cc20370f31072> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3586da7354a132d4bd9cc20370f31072> <http://xmlns.com/foaf/0.1/familyName> "Herrmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3586da7354a132d4bd9cc20370f31072> <http://xmlns.com/foaf/0.1/name> "S Herrmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-daf3490de64e57ade1a7a8510f8f4668> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-daf3490de64e57ade1a7a8510f8f4668> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-daf3490de64e57ade1a7a8510f8f4668> <http://xmlns.com/foaf/0.1/familyName> "Schwagarus"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-daf3490de64e57ade1a7a8510f8f4668> <http://xmlns.com/foaf/0.1/name> "T Schwagarus"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cf2d896815600607837f037a9ac1c4b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4cf2d896815600607837f037a9ac1c4b> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cf2d896815600607837f037a9ac1c4b> <http://xmlns.com/foaf/0.1/familyName> "Hotze"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cf2d896815600607837f037a9ac1c4b> <http://xmlns.com/foaf/0.1/name> "M Hotze"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1fa4933374353cd8a1ae5c80e422b4d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a1fa4933374353cd8a1ae5c80e422b4d> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1fa4933374353cd8a1ae5c80e422b4d> <http://xmlns.com/foaf/0.1/familyName> "Thiede"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1fa4933374353cd8a1ae5c80e422b4d> <http://xmlns.com/foaf/0.1/name> "C Thiede"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4b4e45e41f5031a6e33e489ba2c590fc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4b4e45e41f5031a6e33e489ba2c590fc> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4b4e45e41f5031a6e33e489ba2c590fc> <http://xmlns.com/foaf/0.1/familyName> "Cardaun"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4b4e45e41f5031a6e33e489ba2c590fc> <http://xmlns.com/foaf/0.1/name> "I Cardaun"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5a096c7e2093edaca87eafa22097760> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f5a096c7e2093edaca87eafa22097760> <http://xmlns.com/foaf/0.1/givenName> "GP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5a096c7e2093edaca87eafa22097760> <http://xmlns.com/foaf/0.1/familyName> "Bates"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f5a096c7e2093edaca87eafa22097760> <http://xmlns.com/foaf/0.1/name> "GP Bates"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3923b0223de2526186fe77d50ae8eea6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3923b0223de2526186fe77d50ae8eea6> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3923b0223de2526186fe77d50ae8eea6> <http://xmlns.com/foaf/0.1/familyName> "Herrmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3923b0223de2526186fe77d50ae8eea6> <http://xmlns.com/foaf/0.1/name> "F Herrmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/883500> .
<https://discovery.ucl.ac.uk/id/document/883500> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/883500> <http://www.w3.org/2000/01/rdf-schema#label> "Meso scale discovery-based assays for the detection of aggregated huntingtin (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/883502> .
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<https://discovery.ucl.ac.uk/id/document/883502> <http://www.w3.org/2000/01/rdf-schema#label> "Meso scale discovery-based assays for the detection of aggregated huntingtin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/document/883502> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/883500> .
<https://discovery.ucl.ac.uk/id/document/883502> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/883500> .
<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/883503> .
<https://discovery.ucl.ac.uk/id/document/883503> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/883503> <http://www.w3.org/2000/01/rdf-schema#label> "Meso scale discovery-based assays for the detection of aggregated huntingtin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10072163> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/883504> .
<https://discovery.ucl.ac.uk/id/document/883504> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
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