eprintid: 10071684
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/10/07/16/84
datestamp: 2019-04-05 15:37:20
lastmod: 2020-02-12 23:55:55
status_changed: 2019-10-25 11:56:06
type: article
metadata_visibility: show
creators_name: Martinez-Martin, P
creators_name: Schrag, A
creators_name: Weintraub, D
creators_name: Rizos, A
creators_name: Rodriguez-Blazquez, C
creators_name: Chaudhuri, KR
title: Pilot Study of the International Parkinson and Movement Disorder Society-sponsored Non-motor Rating Scale (MDS-NMS)
ispublished: pub
divisions: UCL
divisions: A01
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: MDS‐NMS, new non‐motor symptoms scale, non‐motor symptoms, Parkinson's disease, pilot study
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Background: Non-motor symptoms (NMS) are integral to Parkinson's disease (PD) and have a detrimental effect on patients and their caregivers. Clinical quantification has been aided by the development of comprehensive assessments such as the Non-Motor Symptoms Questionnaire (NMSQuest) and Scale (NMSS). The NMSS has been widely used in clinical studies and trials; however, since its validation in 2007, our understanding of NMS has changed substantially. With the support of the International Parkinson and Movement Disorder Society (IPMDS), after a detailed peer review an initiative to develop an updated version of NMSS, the MDS-NMS was launched in 2015. Objective: This paper encapsulates the data from the pre-validation phases carried out under the auspices of the IPMDS Non-Motor PD Study Group. Methods: Item selection and wording (formatted as a rater-based tool) were based on the NMSS, literature review, and expert consensus. Neurologists, PD patients, and healthy controls were included in the cognitive pretesting and administration of the preliminary version of the MDS-NMS. Primary data on acceptability and reliability were obtained. Results: The pilot study, carried out in English in the United Kingdom and the United States, demonstrated that the preliminary version of the MDS-NMS was comprehensive, understandable, and appropriate. Data quality was excellent; moderate floor effect was present in patients for most MDS-MNS domains, with some components showing weak internal consistency. The results led to additional instrument modifications. Conclusion: Qualitative and quantitative research results have led to an updated NMSS, the definitive version of the MDS-NMS, which is currently being validated.
date: 2019-03
date_type: published
official_url: https://doi.org/10.1002/mdc3.12728
full_text_type: other
language: eng
verified: verified_manual
elements_id: 1629630
doi: 10.1002/mdc3.12728
lyricists_name: Schrag, Anette
lyricists_id: AESCH71
actors_name: Schrag, Anette
actors_name: Sayed, Imran
actors_id: AESCH71
actors_id: ISAYE60
actors_role: owner
actors_role: impersonator
full_text_status: restricted
publication: Movement Disorders Clinical Practice
volume: 6
number: 3
pagerange: 227-234
issn: 2330-1619
citation:        Martinez-Martin, P;    Schrag, A;    Weintraub, D;    Rizos, A;    Rodriguez-Blazquez, C;    Chaudhuri, KR;      (2019)    Pilot Study of the International Parkinson and Movement Disorder Society-sponsored Non-motor Rating Scale (MDS-NMS).                   Movement Disorders Clinical Practice , 6  (3)   pp. 227-234.    10.1002/mdc3.12728 <https://doi.org/10.1002/mdc3.12728>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10071684/3/Schrag_Pilot%20study_Manuscript_4-12-2018_Clean.pdf