<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10071541> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/title> "Development of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimer's disease"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/abstract> "Detailed knowledge of protein changes in cerebrospinal fluid (CSF) across healthy and diseased individuals would provide a better understanding of the onset and progression of neurodegenerative disorders. In this study, we selected 20 brain-enriched proteins previously identified in CSF by antibody suspension bead arrays (SBA) to be potentially biomarkers for Alzheimer's disease (AD) and verified these using an orthogonal approach. We examined the same set of 94 CSF samples from patients affected by AD (including preclinical and prodromal), mild cognitive impairment (MCI), non-AD dementia and healthy individuals, which had previously been analyzed by SBA. Twenty-eight parallel reaction monitoring (PRM) assays were developed and 13 of them could be validated for protein quantification. Antibody profiles were verified by PRM. For seven proteins, the antibody profiles were highly correlated with the PRM results (r > 0.7) and GAP43, VCAM1 and PSAP were identified as potential markers of preclinical AD. In conclusion, we demonstrate the usefulness of targeted mass spectrometry as a tool for the orthogonal verification of antibody profiling data, suggesting that these complementary methods can be successfully applied for comprehensive exploration of CSF protein levels in neurodegenerative disorders."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/date> "2019-07" .
<https://discovery.ucl.ac.uk/id/document/877814> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/volume> "494" .
<https://discovery.ucl.ac.uk/id/publication/ext-18733492> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-18733492> <http://xmlns.com/foaf/0.1/name> "Clinica Chimica Acta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-18733492> .
<https://discovery.ucl.ac.uk/id/publication/ext-18733492> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:18733492> .
<https://discovery.ucl.ac.uk/id/publication/ext-18733492> <http://purl.org/ontology/bibo/issn> "18733492" .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a26226fc89856005d1993b37f255799b> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-a26226fc89856005d1993b37f255799b> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c6d092d80c6bc9c126f1e911b32cb8e6> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-c6d092d80c6bc9c126f1e911b32cb8e6> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-06d310d4b81fa25122194c44b987a551> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-06d310d4b81fa25122194c44b987a551> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-58c53788a14e7e8b27aeb16d6a99d564> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-58c53788a14e7e8b27aeb16d6a99d564> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5836515b49f44fe2f0385f7d26a89269> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-5836515b49f44fe2f0385f7d26a89269> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-14db7c4b4d52aedc322507199cbbc0bf> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-14db7c4b4d52aedc322507199cbbc0bf> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4fc0008425e8783cf7bb9668d72d4037> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-4fc0008425e8783cf7bb9668d72d4037> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f42ea402edaf2568d32d1e26c6fa6a72> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-f42ea402edaf2568d32d1e26c6fa6a72> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1816eb6c6a6e2cd48e7ef00a56ed6e71> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-1816eb6c6a6e2cd48e7ef00a56ed6e71> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d020fcb2b793724c019eda0d1059d556> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d020fcb2b793724c019eda0d1059d556> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-89622c40ad684d3acf9f1c023f0617af> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-89622c40ad684d3acf9f1c023f0617af> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ae54813a09cd55c4226b3e9db28da02e> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-ae54813a09cd55c4226b3e9db28da02e> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1e940f2497db9a8eb945af75369e391c> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-1e940f2497db9a8eb945af75369e391c> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9772f47093499f7ca1e484eeb297e978> .
<https://discovery.ucl.ac.uk/id/eprint/10071541> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071541#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10071541#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-9772f47093499f7ca1e484eeb297e978> .
<https://discovery.ucl.ac.uk/id/person/ext-5836515b49f44fe2f0385f7d26a89269> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5836515b49f44fe2f0385f7d26a89269> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5836515b49f44fe2f0385f7d26a89269> <http://xmlns.com/foaf/0.1/familyName> "Kotol"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5836515b49f44fe2f0385f7d26a89269> <http://xmlns.com/foaf/0.1/name> "D Kotol"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e940f2497db9a8eb945af75369e391c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1e940f2497db9a8eb945af75369e391c> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e940f2497db9a8eb945af75369e391c> <http://xmlns.com/foaf/0.1/familyName> "Nilsson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e940f2497db9a8eb945af75369e391c> <http://xmlns.com/foaf/0.1/name> "P Nilsson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a26226fc89856005d1993b37f255799b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a26226fc89856005d1993b37f255799b> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a26226fc89856005d1993b37f255799b> <http://xmlns.com/foaf/0.1/familyName> "Andersson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a26226fc89856005d1993b37f255799b> <http://xmlns.com/foaf/0.1/name> "A Andersson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1816eb6c6a6e2cd48e7ef00a56ed6e71> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1816eb6c6a6e2cd48e7ef00a56ed6e71> <http://xmlns.com/foaf/0.1/givenName> "LL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1816eb6c6a6e2cd48e7ef00a56ed6e71> <http://xmlns.com/foaf/0.1/familyName> "Ilag"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1816eb6c6a6e2cd48e7ef00a56ed6e71> <http://xmlns.com/foaf/0.1/name> "LL Ilag"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d020fcb2b793724c019eda0d1059d556> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d020fcb2b793724c019eda0d1059d556> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d020fcb2b793724c019eda0d1059d556> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d020fcb2b793724c019eda0d1059d556> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d092d80c6bc9c126f1e911b32cb8e6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d092d80c6bc9c126f1e911b32cb8e6> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d092d80c6bc9c126f1e911b32cb8e6> <http://xmlns.com/foaf/0.1/familyName> "Remnestål"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6d092d80c6bc9c126f1e911b32cb8e6> <http://xmlns.com/foaf/0.1/name> "J Remnestål"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f42ea402edaf2568d32d1e26c6fa6a72> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f42ea402edaf2568d32d1e26c6fa6a72> <http://xmlns.com/foaf/0.1/givenName> "JM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f42ea402edaf2568d32d1e26c6fa6a72> <http://xmlns.com/foaf/0.1/familyName> "Schwenk"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f42ea402edaf2568d32d1e26c6fa6a72> <http://xmlns.com/foaf/0.1/name> "JM Schwenk"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9772f47093499f7ca1e484eeb297e978> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9772f47093499f7ca1e484eeb297e978> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9772f47093499f7ca1e484eeb297e978> <http://xmlns.com/foaf/0.1/familyName> "Fredolini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9772f47093499f7ca1e484eeb297e978> <http://xmlns.com/foaf/0.1/name> "C Fredolini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4fc0008425e8783cf7bb9668d72d4037> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4fc0008425e8783cf7bb9668d72d4037> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4fc0008425e8783cf7bb9668d72d4037> <http://xmlns.com/foaf/0.1/familyName> "Uhlén"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4fc0008425e8783cf7bb9668d72d4037> <http://xmlns.com/foaf/0.1/name> "M Uhlén"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ae54813a09cd55c4226b3e9db28da02e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ae54813a09cd55c4226b3e9db28da02e> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ae54813a09cd55c4226b3e9db28da02e> <http://xmlns.com/foaf/0.1/familyName> "MÃ¥nberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ae54813a09cd55c4226b3e9db28da02e> <http://xmlns.com/foaf/0.1/name> "A MÃ¥nberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-06d310d4b81fa25122194c44b987a551> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-06d310d4b81fa25122194c44b987a551> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-06d310d4b81fa25122194c44b987a551> <http://xmlns.com/foaf/0.1/familyName> "Nellgård"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-06d310d4b81fa25122194c44b987a551> <http://xmlns.com/foaf/0.1/name> "B Nellgård"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58c53788a14e7e8b27aeb16d6a99d564> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-58c53788a14e7e8b27aeb16d6a99d564> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-58c53788a14e7e8b27aeb16d6a99d564> <http://xmlns.com/foaf/0.1/familyName> "Vunk"^^<http://www.w3.org/2001/XMLSchema#string> .
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