TY - JOUR N1 - Copyright © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. TI - Increasing incidence of adult idiopathic inflammatory myopathies in the City of Salford, UK: A 10-year epidemiological study Y1 - 2018/// UR - https://doi.org/10.1093/rap/rky035 ID - discovery10071492 VL - 2 JF - Rheumatology Advances in Practice N2 - Objectives. The aim was to identify and characterize all incident adult cases of idiopathic inflammatory myopathies (IIM) between 1 January 2007 and 31 December 2016 in the City of Salford, UK. / Methods. Adults first diagnosed with IIM within the study period were identified by: a Salford Royal NHS Foundation Trust (SRFT) inpatient episode IIM-specific ICD-10 coding search; all new patient appointments to SRFT neuromuscular outpatient clinics; and all Salford residents enrolled within the UKMYONET study. All patients with definite IIM by the 2017 EULAR/ACR classification criteria were included, as were probable cases if consensus expert opinion agreed. Cases were excluded if < 18 years of age at disease onset, if they did not meet probable criteria or when probable but expert opinion concluded a non-IIM diagnosis. / Results. The multimodal case ascertainment identified 1156 cases which, after review and application of exclusion criteria, resulted in 32 incident cases during the study period. Twenty-three of 32 were female, with a mean age of 58.1 years. The mean incidence of adult IIM was 17.6/1 000 000 person years, and higher for females than for males (25.2 vs 10.0/1 000 000 person years, respectively). A significant incidence increase over time was apparent (13.6 vs 21.4/1 000 000 person years; P=0.032). Using EULAR/ACR classification criteria, the largest IIM subtype (21/32) was PM, followed by DM (8/32), IBM (2/32) and amyopathic DM (1/32). Expert opinion subtype differed from EULAR/ACR classification criteria in 19/32 cases. / Conclusion. The incidence of adult IIM in Salford is 17.6/1 000 000 person years, higher in females, and is increasing over time. Disagreement exists between EULAR/ACR-derived and expert opinionderived IIM subtype assignments. A1 - Parker, MJS A1 - Oldroyd, A A1 - Roberts, ME A1 - Ollier, WE A1 - New, RP A1 - Cooper, RG A1 - Chinoy, H A1 - Ahmed, Y A1 - Armstrong, R A1 - Bernstein, R A1 - Black, C A1 - Bowman, S A1 - Bruce, I A1 - Butler, R A1 - Carty, J A1 - Chattopadhyay, C A1 - Chelliah, E A1 - Clarke, F A1 - Dawes, P A1 - Devlin, J A1 - Edwards, C A1 - Emery, P A1 - Fordham, J A1 - Fraser, A A1 - Gaston, H A1 - Gordon, P A1 - Griffiths, B A1 - Gunawardena, H A1 - Hall, F A1 - Harrison, B A1 - Hay, E A1 - Horden, L A1 - Isaacs, J A1 - Jones, A A1 - Kamath, S A1 - Kennedy, T A1 - Kitas, G A1 - Klimiuk, P A1 - Knights, S A1 - Lambert, J A1 - Lanyon, P A1 - Laxminarayan, R A1 - Lecky, B A1 - Luqmani, R A1 - Marks, J A1 - Martin, M A1 - McGonagle, D A1 - McHugh, N A1 - McKenna, F A1 - McLaren, J A1 - McMahon, M A1 - McRorie, E A1 - Merry, P A1 - Miles, S A1 - Miller, J A1 - Nicholls, A A1 - Nixon, J A1 - Ong, V A1 - Over, K A1 - Packham, J A1 - Pipitone, N A1 - Plant, M A1 - Pountain, G A1 - Pullar, T A1 - Sanders, P A1 - Scott, D A1 - Scott, D A1 - Shadforth, M A1 - Sheeran, T A1 - Srinivasan, A A1 - Swinson, D A1 - Teh, LS A1 - Webley, M A1 - Williams, B A1 - Winer, J SN - 2514-1775 AV - public IS - 2 ER -