<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10071403> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/title> "Unsupervised data-driven stratification of mentalizing heterogeneity in autism"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/abstract> "Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a clustering approach taken from genomics and systems biology on two large independent cognitive datasets of adults with and without ASC (n = 694; n = 249), we find replicable evidence for 5 discrete ASC subgroups that are highly differentiated in item-level performance on an explicit mentalizing task tapping ability to read complex emotion and mental states from the eye region of the face (Reading the Mind in the Eyes Test; RMET). Three subgroups comprising 45-62% of ASC adults show evidence for large impairments (Cohen's d = -1.03 to -11.21), while other subgroups are effectively unimpaired. These findings delineate robust natural subdivisions within the ASC population that may allow for more individualized inferences and accelerate research towards precision medicine goals."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/date> "2016-10-18" . <https://discovery.ucl.ac.uk/id/document/876619> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/volume> "6" . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://xmlns.com/foaf/0.1/name> "Scientific Reports"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/isPartOf> 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<http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eecc91da965b675cffc324138cb12812> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-eecc91da965b675cffc324138cb12812> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fd1a082f1a487e96aba1ed75269947f1> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-fd1a082f1a487e96aba1ed75269947f1> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-27ecf17bae2ece1529c954fdd14b7bf2> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-27ecf17bae2ece1529c954fdd14b7bf2> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1e63687c5cef0d3c2b699b3a1135a16f> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-1e63687c5cef0d3c2b699b3a1135a16f> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6f6e0ef5041a20260306952c0964fbf6> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-6f6e0ef5041a20260306952c0964fbf6> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-73cad619058d2585462b5f4e50b78752> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-73cad619058d2585462b5f4e50b78752> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e5067009c1912be50123f40acf393e81> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-e5067009c1912be50123f40acf393e81> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-131c5d5abdf7c67c85b324d3dc10f494> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-131c5d5abdf7c67c85b324d3dc10f494> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-02f1522d382f23c8ef856e5fab3a1fb8> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-02f1522d382f23c8ef856e5fab3a1fb8> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-12facf72225ec0dac07541ecac41f3ec> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-12facf72225ec0dac07541ecac41f3ec> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f2042e4eb9658aafb6cab8b24eb501a0> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-f2042e4eb9658aafb6cab8b24eb501a0> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-16b88ea5cfe1208fb5987fee692bb19d> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-16b88ea5cfe1208fb5987fee692bb19d> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6cbe06a728bb1e5cae4211442f763801> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-6cbe06a728bb1e5cae4211442f763801> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-daa2eef07897af3f01e2db7efc3a5aa3> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-daa2eef07897af3f01e2db7efc3a5aa3> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-014d2a8f12134d12e0d5862ce4941bc6> . <https://discovery.ucl.ac.uk/id/eprint/10071403> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> . <https://discovery.ucl.ac.uk/id/eprint/10071403#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-014d2a8f12134d12e0d5862ce4941bc6> . <https://discovery.ucl.ac.uk/id/person/ext-131c5d5abdf7c67c85b324d3dc10f494> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-131c5d5abdf7c67c85b324d3dc10f494> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-131c5d5abdf7c67c85b324d3dc10f494> <http://xmlns.com/foaf/0.1/familyName> "Suckling"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-131c5d5abdf7c67c85b324d3dc10f494> <http://xmlns.com/foaf/0.1/name> "J Suckling"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73cad619058d2585462b5f4e50b78752> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-73cad619058d2585462b5f4e50b78752> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73cad619058d2585462b5f4e50b78752> <http://xmlns.com/foaf/0.1/familyName> "Chakrabarti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73cad619058d2585462b5f4e50b78752> <http://xmlns.com/foaf/0.1/name> "B Chakrabarti"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12facf72225ec0dac07541ecac41f3ec> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-12facf72225ec0dac07541ecac41f3ec> <http://xmlns.com/foaf/0.1/givenName> "."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12facf72225ec0dac07541ecac41f3ec> <http://xmlns.com/foaf/0.1/familyName> "MRC AIMS Consortium"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-12facf72225ec0dac07541ecac41f3ec> <http://xmlns.com/foaf/0.1/name> ". MRC AIMS Consortium"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e5067009c1912be50123f40acf393e81> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e5067009c1912be50123f40acf393e81> <http://xmlns.com/foaf/0.1/givenName> "ANV"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e5067009c1912be50123f40acf393e81> <http://xmlns.com/foaf/0.1/familyName> "Ruigrok"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e5067009c1912be50123f40acf393e81> <http://xmlns.com/foaf/0.1/name> "ANV Ruigrok"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-fd1a082f1a487e96aba1ed75269947f1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-fd1a082f1a487e96aba1ed75269947f1> 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