TY  - JOUR
VL  - 10
ID  - discovery10071093
AV  - public
A1  - Riva, A
A1  - Mehta, G
SN  - 1664-3224
EP  - 7
KW  - cirrhosis
KW  -  ACLF
KW  -  ARLD
KW  -  ALD
KW  -  alcoholic hepatitis
KW  -  innate immune cell
KW  -  myeloid
KW  -  immune checkpoint
UR  - https://doi.org/10.3389/fimmu.2019.00167
Y1  - 2019/02//
PB  - FRONTIERS MEDIA SA
N2  - Many aspects of the innate immune system have been studied in cirrhosis,
and abnormalities have been described supporting both a pro-inflammatory and
anti-inflammatory phenotype of myeloid cells. However, the findings of these studies
vary by stage of disease and methodology. The recent description of the syndrome of
acute-on-chronic liver failure (ACLF) has refined our understanding of the natural history
of cirrhosis. In this context, we review the regulatory mechanisms at play that contribute
to the immune abnormalities described in advanced liver disease. Specifically, we review
the evidence for epigenetic mechanisms regulating monocyte phenotype, and the role
of checkpoint receptors on regulating innate and adaptive immune cell function.
TI  - Regulation of Monocyte-Macrophage Responses in Cirrhosis-Role of Innate Immune Programming and Checkpoint Receptors
JF  - Frontiers in Immunology
N1  - © 2019 Riva and Mehta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/
ER  -