eprintid: 10070489
rev_number: 43
eprint_status: archive
userid: 608
dir: disk0/10/07/04/89
datestamp: 2019-03-20 15:32:45
lastmod: 2021-12-16 01:35:03
status_changed: 2020-03-09 12:05:43
type: article
metadata_visibility: show
creators_name: Chua, YW
creators_name: Lewis, G
creators_name: Easter, A
creators_name: Lewis, G
creators_name: Solmi, F
title: Eighteen-year trajectories of depressive symptoms in mothers with a lifetime eating disorder: findings from the ALSPAC cohort
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
keywords: ALSPAC; eating disorders; depression; parental mental health;
perinatal mental health.
note: This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Background
Two longitudinal studies have shown that depressive symptoms in women with eating disorders might improve in the antenatal and early postnatal periods. No study has followed up women beyond 8 months postnatal.

Aims
To investigate long-term trajectories of depressive symptoms in mothers with lifetime self-reported eating disorders.

Method
Using data from the Avon Longitudinal Study of Parents and Children and multilevel growth curves we modelled trajectories of depressive symptoms from the 18th week of pregnancy to 18 years postnatal in women with lifetime self-reported anorexia nervosa, bulimia nervosa or both anorexia and bulimia nervosa. As sensitivity analyses we also investigated these trajectories using quintiles of a continuous measure of body image in pregnancy.

Results
Of the 9276 women in our main sample, 126 (1.4%) reported a lifetime diagnosis of anorexia nervosa, 153 (1.6%) of bulimia nervosa and 60 (0.6%) of both anorexia and bulimia nervosa. Women with lifetime eating disorders had greater depressive symptoms scores than women with no eating disorders, before and after adjustment for confounders (anorexia nervosa: 2.10, 95% CI 1.36–2.83; bulimia nervosa: 2.28, 95% CI: 1.61–2.94, both anorexia and bulimia nervosa: 2.86, 95% CI 1.81–3.90). We also observed a dose–response association between greater body image and eating concerns in pregnancy and more severe trajectories of depressive symptoms, even after adjusting for lifetime eating disorders which also remained independently associated with greater depressive symptoms.

Conclusions
Women with eating disorders experience persistently greater depressive symptoms across the life-course. More training for practitioners and midwives on how to recognise eating disorders in pregnancy could help to identify depressive symptoms and reduce the long-term burden of disease resulting from this comorbidity.
date: 2020-02
date_type: published
publisher: Royal College of Psychiatrists
official_url: https://doi.org/10.1192/bjp.2019.89
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1641297
doi: 10.1192/bjp.2019.89
lyricists_name: Lewis, Gemma
lyricists_name: Lewis, Glyn
lyricists_name: Solmi, Francesca
lyricists_id: GLEWI99
lyricists_id: GHLEW69
lyricists_id: FSOLM62
actors_name: Novi, Maya
actors_id: MNOVI52
actors_role: owner
full_text_status: public
publication: British Journal of Psychiatry
volume: 216
number: 2
pagerange: 90-96
citation:        Chua, YW;    Lewis, G;    Easter, A;    Lewis, G;    Solmi, F;      (2020)    Eighteen-year trajectories of depressive symptoms in mothers with a lifetime eating disorder: findings from the ALSPAC cohort.                   British Journal of Psychiatry , 216  (2)   pp. 90-96.    10.1192/bjp.2019.89 <https://doi.org/10.1192/bjp.2019.89>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10070489/1/Lewis%20VoR%20Eighteen-year%20trajectories%20of%20depressive%20symptoms%20in%20mothers%20with%20a%20lifetime%20eating%20disorder.pdf