eprintid: 10069728
rev_number: 24
eprint_status: archive
userid: 608
dir: disk0/10/06/97/28
datestamp: 2019-03-08 15:29:13
lastmod: 2021-09-26 23:10:49
status_changed: 2019-03-08 15:29:13
type: article
metadata_visibility: show
creators_name: Silverwood, RJ
creators_name: Forbes, HJ
creators_name: Abuabara, K
creators_name: Ascott, A
creators_name: Schmidt, M
creators_name: Schmidt, SAJ
creators_name: Smeeth, L
creators_name: Langan, SM
title: Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study
ispublished: pub
divisions: UCL
divisions: B16
divisions: B14
divisions: J81
keywords: Dermatology
note: Copyright © 2018, British Medical Journal Publishing Group. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/.
abstract: OBJECTIVE: To investigate whether adults with atopic eczema are at an increased risk of cardiovascular disease and whether the risk varies by atopic eczema severity and condition activity over time. DESIGN: Population based matched cohort study. SETTING: UK electronic health records from the Clinical Practice Research Datalink, Hospital Episode Statistics, and data from the Office for National Statistics, 1998-2015. PARTICIPANTS: Adults with a diagnosis of atopic eczema, matched (on age, sex, general practice, and calendar time) to up to five patients without atopic eczema. MAIN OUTCOME MEASURES: Cardiovascular outcomes (myocardial infarction, unstable angina, heart failure, atrial fibrillation, stroke, and cardiovascular death). RESULTS: 387 439 patients with atopic eczema were matched to 1 528 477 patients without atopic eczema. The median age was 43 at cohort entry and 66% were female. Median follow-up was 5.1 years. Evidence of a 10% to 20% increased hazard for the non-fatal primary outcomes for patients with atopic eczema was found by using Cox regression stratified by matched set. There was a strong dose-response relation with severity of atopic eczema. Patients with severe atopic eczema had a 20% increase in the risk of stroke (hazard ratio 1.22, 99% confidence interval 1.01 to 1.48), 40% to 50% increase in the risk of myocardial infarction, unstable angina, atrial fibrillation, and cardiovascular death, and 70% increase in the risk of heart failure (hazard ratio 1.69, 99% confidence interval 1.38 to 2.06). Patients with the most active atopic eczema (active >50% of follow-up) were also at a greater risk of cardiovascular outcomes. Additional adjustment for cardiovascular risk factors as potential mediators partially attenuated the point estimates, though associations persisted for severe atopic eczema. CONCLUSIONS: Severe and predominantly active atopic eczema are associated with an increased risk of cardiovascular outcomes. Targeting cardiovascular disease prevention strategies among these patients should be considered.
date: 2018-05-26
date_type: published
official_url: https://doi.org/10.1136/bmj.k1786
oa_status: green
full_text_type: pub
pmcid: PMC6190010
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1634824
doi: 10.1136/bmj.k1786
lyricists_name: Silverwood, Richard
lyricists_id: RSILV59
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: BMJ
volume: 361
number: 8154
article_number: k1786
issn: 0959-8138
citation:        Silverwood, RJ;    Forbes, HJ;    Abuabara, K;    Ascott, A;    Schmidt, M;    Schmidt, SAJ;    Smeeth, L;           Silverwood, RJ;  Forbes, HJ;  Abuabara, K;  Ascott, A;  Schmidt, M;  Schmidt, SAJ;  Smeeth, L;  Langan, SM;   - view fewer <#>    (2018)    Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study.                   BMJ , 361  (8154)    , Article k1786.  10.1136/bmj.k1786 <https://doi.org/10.1136/bmj.k1786>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10069728/1/Silverwood_Severe%20and%20predominantly%20active%20atopic%20eczema%20in%20adulthood%20and%20long%20term%20risk%20of%20cardiovascular%20disease.%20Population%20based%20cohort%20study_VoR.pdf