eprintid: 10069276 rev_number: 48 eprint_status: archive userid: 608 dir: disk0/10/06/92/76 datestamp: 2019-03-01 17:02:10 lastmod: 2021-10-10 22:28:01 status_changed: 2019-03-01 17:02:10 type: article metadata_visibility: show creators_name: Wirestam, L creators_name: Enocsson, H creators_name: Skogh, T creators_name: Padyukov, L creators_name: Jönsen, A creators_name: Urowitz, MB creators_name: Gladman, DD creators_name: Romero-Diaz, J creators_name: Bae, S-C creators_name: Fortin, PR creators_name: Sanchez-Guerrero, J creators_name: Clarke, AE creators_name: Bernatsky, S creators_name: Gordon, C creators_name: Hanly, JG creators_name: Wallace, D creators_name: Isenberg, DA creators_name: Rahman, A creators_name: Merrill, J creators_name: Ginzler, E creators_name: Alarcón, GS creators_name: Chatham, WW creators_name: Petri, M creators_name: Khamashta, M creators_name: Aranow, C creators_name: Mackay, M creators_name: Dooley, MA creators_name: Manzi, S creators_name: Ramsey-Goldman, R creators_name: Nived, O creators_name: Steinsson, K creators_name: Zoma, A creators_name: Ruiz-Irastorza, G creators_name: Lim, S creators_name: Kalunian, K creators_name: Inanc, M creators_name: Vollenhoven, RV creators_name: Ramos-Casals, M creators_name: Kamen, DL creators_name: Jacobsen, S creators_name: Peschken, C creators_name: Askanase, A creators_name: Stoll, T creators_name: Bruce, IN creators_name: Wetterö, J creators_name: Sjöwall, C title: Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G90 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: OBJECTIVE: In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. METHODS: We included 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who had 5 years of followup data available. All patients fulfilled the 1997 American College of Rheumatology (ACR) criteria. Baseline sera from patients and from age- and sex-matched population-based controls were analyzed for OPN using ELISA. Disease activity and damage were assessed at each annual followup visit using the SLE Disease Activity Index 2000 (SLEDAI-2K) and the SLICC/ACR damage index (SDI), respectively. RESULTS: Compared to controls, baseline OPN was raised 4-fold in SLE cases (p < 0.0001). After relevant adjustments in a binary logistic regression model, OPN levels failed to significantly predict global damage accrual defined as SDI ≥ 1 at 5 years. However, baseline OPN correlated with SLEDAI-2K at enrollment into the cohort (r = 0.27, p < 0.0001), and patients with high disease activity (SLEDAI-2K ≥ 5) had raised serum OPN (p < 0.0001). In addition, higher OPN levels were found in patients with persistent disease activity (p = 0.0006), in cases with renal involvement (p < 0.0001) and impaired estimated glomerular filtration rate (p = 0.01). CONCLUSION: The performance of OPN to predict development of organ damage was not impressive. However, OPN associated significantly with lupus nephritis and with raised disease activity at enrollment, as well as over time. date: 2019-03-01 date_type: published official_url: https://doi.org/10.3899/jrheum.180713 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1622193 doi: 10.3899/jrheum.180713 pii: jrheum.180713 lyricists_name: Isenberg, David lyricists_name: Rahman, Mohammed lyricists_id: DAISE40 lyricists_id: ARAHM26 actors_name: Rahman, Mohammed actors_id: ARAHM26 actors_role: owner full_text_status: public publication: Journal of Rheumatology volume: 46 number: 3 article_number: jrheum.180713 event_location: Canada issn: 0315-162X citation: Wirestam, L; Enocsson, H; Skogh, T; Padyukov, L; Jönsen, A; Urowitz, MB; Gladman, DD; ... Sjöwall, C; + view all <#> Wirestam, L; Enocsson, H; Skogh, T; Padyukov, L; Jönsen, A; Urowitz, MB; Gladman, DD; Romero-Diaz, J; Bae, S-C; Fortin, PR; Sanchez-Guerrero, J; Clarke, AE; Bernatsky, S; Gordon, C; Hanly, JG; Wallace, D; Isenberg, DA; Rahman, A; Merrill, J; Ginzler, E; Alarcón, GS; Chatham, WW; Petri, M; Khamashta, M; Aranow, C; Mackay, M; Dooley, MA; Manzi, S; Ramsey-Goldman, R; Nived, O; Steinsson, K; Zoma, A; Ruiz-Irastorza, G; Lim, S; Kalunian, K; Inanc, M; Vollenhoven, RV; Ramos-Casals, M; Kamen, DL; Jacobsen, S; Peschken, C; Askanase, A; Stoll, T; Bruce, IN; Wetterö, J; Sjöwall, C; - view fewer <#> (2019) Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort. Journal of Rheumatology , 46 (3) , Article jrheum.180713. 10.3899/jrheum.180713 <https://doi.org/10.3899/jrheum.180713>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10069276/9/Rahman%20OPN%20in%20SLICC%20180828_Clean.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10069276/15/Rahman%20Table%201%20180912.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10069276/20/Rahman%20Table%202.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10069276/27/Rahman%20Table%203.pdf