eprintid: 10069081 rev_number: 44 eprint_status: archive userid: 608 dir: disk0/10/06/90/81 datestamp: 2019-03-01 11:22:09 lastmod: 2021-09-19 22:56:45 status_changed: 2019-05-29 15:15:59 type: article metadata_visibility: show creators_name: Slator, P creators_name: Hutter, J creators_name: Palombo, M creators_name: Jackson, LH creators_name: Ho, A creators_name: Panagiotaki, E creators_name: Chappell, LC creators_name: Rutherford, MA creators_name: Hajnal, JV creators_name: Alexander, D title: Combined Diffusion-Relaxometry MRI to Identify Dysfunction in the Human Placenta ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F48 keywords: placenta, diffusion, relaxometry, microstructure, multimodal MRI, inverse Laplace transform note: © 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: Purpose: A combined diffusion‐relaxometry MR acquisition and analysis pipeline for in vivo human placenta, which allows for exploration of coupling between urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0028 and apparent diffusion coefficient (ADC) measurements in a sub 10‐minute scan time. // Methods: We present a novel acquisition combining a diffusion prepared spin echo with subsequent gradient echoes. The placentas of 17 pregnant women were scanned in vivo, including both healthy controls and participants with various pregnancy complications. We estimate the joint urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0029‐ADC spectra using an inverse Laplace transform. // Results: urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0030‐ADC spectra demonstrate clear quantitative separation between normal and dysfunctional placentas. // Conclusions: Combined urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0031‐diffusivity MRI is promising for assessing fetal and maternal health during pregnancy. The urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0032‐ADC spectrum potentially provides additional information on tissue microstructure, compared to measuring these two contrasts separately. The presented method is immediately applicable to the study of other organs. date: 2019-07 date_type: published publisher: Wiley-Blackwell official_url: https://doi.org/10.1002/mrm.27733 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1633603 doi: 10.1002/mrm.27733 lyricists_name: Alexander, Daniel lyricists_name: Palombo, Marco lyricists_name: Panagiotaki, Eleftheria lyricists_name: Slator, Patrick lyricists_id: DALEX06 lyricists_id: MPALO05 lyricists_id: EPANA29 lyricists_id: PJSLA44 actors_name: Slator, Patrick actors_id: PJSLA44 actors_role: owner full_text_status: public publication: Magnetic Resonance in Medicine volume: 82 number: 1 pagerange: 95-106 issn: 0740-3194 citation: Slator, P; Hutter, J; Palombo, M; Jackson, LH; Ho, A; Panagiotaki, E; Chappell, LC; ... Alexander, D; + view all <#> Slator, P; Hutter, J; Palombo, M; Jackson, LH; Ho, A; Panagiotaki, E; Chappell, LC; Rutherford, MA; Hajnal, JV; Alexander, D; - view fewer <#> (2019) Combined Diffusion-Relaxometry MRI to Identify Dysfunction in the Human Placenta. Magnetic Resonance in Medicine , 82 (1) pp. 95-106. 10.1002/mrm.27733 <https://doi.org/10.1002/mrm.27733>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10069081/7/Slator_et_al-2019-Magnetic_Resonance_in_Medicine.pdf