%I Wiley-Blackwell
%P 95-106
%X Purpose: A combined diffusion‐relaxometry MR acquisition and analysis pipeline for in vivo human placenta, which allows for exploration of coupling between urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0028 and apparent diffusion coefficient (ADC) measurements in a sub 10‐minute scan time. // 

Methods: We present a novel acquisition combining a diffusion prepared spin echo with subsequent gradient echoes. The placentas of 17 pregnant women were scanned in vivo, including both healthy controls and participants with various pregnancy complications. We estimate the joint urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0029‐ADC spectra using an inverse Laplace transform. // 

Results: urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0030‐ADC spectra demonstrate clear quantitative separation between normal and dysfunctional placentas. // 

Conclusions: Combined urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0031‐diffusivity MRI is promising for assessing fetal and maternal health during pregnancy. The urn:x-wiley:07403194:media:mrm27733:mrm27733-math-0032‐ADC spectrum potentially provides additional information on tissue microstructure, compared to measuring these two contrasts separately. The presented method is immediately applicable to the study of other organs.
%A P Slator
%A J Hutter
%A M Palombo
%A LH Jackson
%A A Ho
%A E Panagiotaki
%A LC Chappell
%A MA Rutherford
%A JV Hajnal
%A D Alexander
%T Combined Diffusion-Relaxometry MRI to Identify Dysfunction in the Human Placenta
%O © 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
%D 2019
%K placenta, diffusion, relaxometry, microstructure, multimodal MRI, inverse Laplace transform
%L discovery10069081
%V 82
%N 1
%J Magnetic Resonance in Medicine