<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10068066> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/title> "The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/abstract> "The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific antibodies. However, amyloid IHC is qualitative, non-standardised, requires operator expertise, and not infrequently fails to produce definitive results. More recently, laser dissection mass spectrometry (LDMS) has been developed as an alternative method to characterise amyloid in tissue sections. We sought to compare these techniques in a real world setting. During 2017, we performed LDMS on 640 formalin-fixed biopsies containing amyloid (CR+ve) comprising all 320 cases that could not be typed by IHC (IHC-ve) and 320 randomly selected CR+ve samples that had been typed (IHC+ve). In addition, we studied 60 biopsies from patients in whom there was a strong suspicion of amyloidosis, but in whom histology was non-diagnostic (CR-ve). Comprehensive clinical assessments were conducted in 532 (76%) of cases. Among the 640 CR+ve samples, 602 (94%) contained ≥ 2 of 3 amyloid signature proteins (ASPs) on LDMS (ASP+ve) supporting the presence of amyloid. 49 of the 60 CR-ve samples were ASP-ve; 7/11 that were ASP+ve were glomerular. The amyloid fibril protein was identified by LDMS in 255/320 (80%) of the IHC-ve samples and in a total of 545/640 (85%) cases overall. The LDMS and IHC techniques yielded discordant results in only 7/320 (2%) cases. CR histology and LDMS are corroborative for diagnosis of amyloid, but LDMS is superior to IHC for confirming amyloid type. This article is protected by copyright. All rights reserved."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/date> "2019-07" .
<https://discovery.ucl.ac.uk/id/document/944655> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/volume> "5" .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/issue> "3" .
<https://discovery.ucl.ac.uk/id/publication/ext-20564538> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-20564538> <http://xmlns.com/foaf/0.1/name> "Journal of Pathology: Clinical Research"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20564538> .
<https://discovery.ucl.ac.uk/id/publication/ext-20564538> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20564538> .
<https://discovery.ucl.ac.uk/id/publication/ext-20564538> <http://purl.org/ontology/bibo/issn> "20564538" .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5339fa5be8b1f2b890f8d7dd6398f02a> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-5339fa5be8b1f2b890f8d7dd6398f02a> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e7760e3ef0577cf9eb0a0a80a6ade0b4> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-e7760e3ef0577cf9eb0a0a80a6ade0b4> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c51d3608a224af2203138410c7af5669> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-c51d3608a224af2203138410c7af5669> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6ba7eeceb9c99f5f5bfd9e9c85d67435> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-6ba7eeceb9c99f5f5bfd9e9c85d67435> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-733533dc4373d6cfdb4c6f30371dc974> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-733533dc4373d6cfdb4c6f30371dc974> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6fc15f75155f03ecaf07e43e3fd9fc68> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-6fc15f75155f03ecaf07e43e3fd9fc68> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b5d0a1518a809e43dd57baac09c8a067> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-b5d0a1518a809e43dd57baac09c8a067> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-db741e63e7ab583e8982fd7c95ae5794> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-db741e63e7ab583e8982fd7c95ae5794> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-60c9f572cf43e3fd212fc3ba9958a38c> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-60c9f572cf43e3fd212fc3ba9958a38c> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8a5bb8a6c0727802e8c36f1753738d9f> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-8a5bb8a6c0727802e8c36f1753738d9f> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3080622bd18a265795b3c86f73067d44> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3080622bd18a265795b3c86f73067d44> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1015b6aef8670c721ceeee7d0ddc264f> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-1015b6aef8670c721ceeee7d0ddc264f> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-475d1e785664bc2b11277a2cf42a91e7> .
<https://discovery.ucl.ac.uk/id/eprint/10068066> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10068066#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10068066#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-475d1e785664bc2b11277a2cf42a91e7> .
<https://discovery.ucl.ac.uk/id/person/ext-db741e63e7ab583e8982fd7c95ae5794> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-db741e63e7ab583e8982fd7c95ae5794> <http://xmlns.com/foaf/0.1/givenName> "AD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db741e63e7ab583e8982fd7c95ae5794> <http://xmlns.com/foaf/0.1/familyName> "Wechalekar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db741e63e7ab583e8982fd7c95ae5794> <http://xmlns.com/foaf/0.1/name> "AD Wechalekar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e7760e3ef0577cf9eb0a0a80a6ade0b4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e7760e3ef0577cf9eb0a0a80a6ade0b4> <http://xmlns.com/foaf/0.1/givenName> "JA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e7760e3ef0577cf9eb0a0a80a6ade0b4> <http://xmlns.com/foaf/0.1/familyName> "Gilbertson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e7760e3ef0577cf9eb0a0a80a6ade0b4> <http://xmlns.com/foaf/0.1/name> "JA Gilbertson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1015b6aef8670c721ceeee7d0ddc264f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1015b6aef8670c721ceeee7d0ddc264f> <http://xmlns.com/foaf/0.1/givenName> "GW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1015b6aef8670c721ceeee7d0ddc264f> <http://xmlns.com/foaf/0.1/familyName> "Taylor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1015b6aef8670c721ceeee7d0ddc264f> <http://xmlns.com/foaf/0.1/name> "GW Taylor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3080622bd18a265795b3c86f73067d44> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3080622bd18a265795b3c86f73067d44> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3080622bd18a265795b3c86f73067d44> <http://xmlns.com/foaf/0.1/familyName> "Bellotti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3080622bd18a265795b3c86f73067d44> <http://xmlns.com/foaf/0.1/name> "V Bellotti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-733533dc4373d6cfdb4c6f30371dc974> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-733533dc4373d6cfdb4c6f30371dc974> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-733533dc4373d6cfdb4c6f30371dc974> <http://xmlns.com/foaf/0.1/familyName> "Rendell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-733533dc4373d6cfdb4c6f30371dc974> <http://xmlns.com/foaf/0.1/name> "N Rendell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6fc15f75155f03ecaf07e43e3fd9fc68> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6fc15f75155f03ecaf07e43e3fd9fc68> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6fc15f75155f03ecaf07e43e3fd9fc68> <http://xmlns.com/foaf/0.1/familyName> "Canetti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6fc15f75155f03ecaf07e43e3fd9fc68> <http://xmlns.com/foaf/0.1/name> "D Canetti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5339fa5be8b1f2b890f8d7dd6398f02a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5339fa5be8b1f2b890f8d7dd6398f02a> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5339fa5be8b1f2b890f8d7dd6398f02a> <http://xmlns.com/foaf/0.1/familyName> "Rezk"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5339fa5be8b1f2b890f8d7dd6398f02a> <http://xmlns.com/foaf/0.1/name> "T Rezk"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-60c9f572cf43e3fd212fc3ba9958a38c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-60c9f572cf43e3fd212fc3ba9958a38c> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-60c9f572cf43e3fd212fc3ba9958a38c> <http://xmlns.com/foaf/0.1/familyName> "Bass"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-60c9f572cf43e3fd212fc3ba9958a38c> <http://xmlns.com/foaf/0.1/name> "P Bass"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-475d1e785664bc2b11277a2cf42a91e7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-475d1e785664bc2b11277a2cf42a91e7> <http://xmlns.com/foaf/0.1/givenName> "JD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-475d1e785664bc2b11277a2cf42a91e7> <http://xmlns.com/foaf/0.1/familyName> "Gillmore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-475d1e785664bc2b11277a2cf42a91e7> <http://xmlns.com/foaf/0.1/name> "JD Gillmore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a5bb8a6c0727802e8c36f1753738d9f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8a5bb8a6c0727802e8c36f1753738d9f> <http://xmlns.com/foaf/0.1/givenName> "PN"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a5bb8a6c0727802e8c36f1753738d9f> <http://xmlns.com/foaf/0.1/familyName> "Hawkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a5bb8a6c0727802e8c36f1753738d9f> <http://xmlns.com/foaf/0.1/name> "PN Hawkins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c51d3608a224af2203138410c7af5669> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c51d3608a224af2203138410c7af5669> <http://xmlns.com/foaf/0.1/givenName> "PP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c51d3608a224af2203138410c7af5669> <http://xmlns.com/foaf/0.1/familyName> "Mangione"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c51d3608a224af2203138410c7af5669> <http://xmlns.com/foaf/0.1/name> "PP Mangione"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6ba7eeceb9c99f5f5bfd9e9c85d67435> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6ba7eeceb9c99f5f5bfd9e9c85d67435> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6ba7eeceb9c99f5f5bfd9e9c85d67435> <http://xmlns.com/foaf/0.1/familyName> "Rowczenio"^^<http://www.w3.org/2001/XMLSchema#string> .
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