eprintid: 10067814
rev_number: 24
eprint_status: archive
userid: 608
dir: disk0/10/06/78/14
datestamp: 2019-02-13 11:05:28
lastmod: 2021-09-20 22:28:26
status_changed: 2019-02-13 11:05:28
type: article
metadata_visibility: show
creators_name: Cokal, D
creators_name: Zimmerer, V
creators_name: Varley, R
creators_name: Watson, S
creators_name: Hinzen, W
title: Comprehension of embedded clauses in schizophrenia with and without formal thought disorder
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D05
divisions: F71
keywords: Schizophrenia, Formal Thought Disorder, Comprehension, Syntax, Language dysfunction
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Formal thought disorder (FTD) in schizophrenia (SZ) is clinically manifest primarily through language production, where linguistic studies have reported numerous anomalies including lesser use of embedded clauses. Here we explored whether problems of language may extend to comprehension and clause embedding in particular. A sentence-picture matching task was designed with two conditions in which embedded clauses were either presupposed as true (factive) or not. Performance across these two conditions was compared in people with SZ and moderate-to-severe FTD (SZ+FTD), SZ with minimal FTD (SZ-FTD), first degree relatives of people with SZ, and neurotypical controls. The SZ+FTD group performed significantly worse than all others in both conditions, and worse in the non-factive than the factive one. These results demonstrate language dysfunction in comprehension specific to FTD in a critical aspect of grammatical complexity and its associated meaning, which has been independently known to be cognitively significant as well.
date: 2019-05
date_type: published
official_url: http://doi.org/10.1097/NMD.0000000000000981
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1628045
doi: 10.1097/NMD.0000000000000981
lyricists_name: Varley, Rosemary
lyricists_name: Zimmerer, Vitor
lyricists_id: RAVAR08
lyricists_id: VCZIM62
actors_name: Zimmerer, Vitor
actors_id: VCZIM62
actors_role: owner
full_text_status: public
publication: The Journal of Nervous and Mental Disease
volume: 207
number: 5
pagerange: 384-392
citation:        Cokal, D;    Zimmerer, V;    Varley, R;    Watson, S;    Hinzen, W;      (2019)    Comprehension of embedded clauses in schizophrenia with and without formal thought disorder.                   The Journal of Nervous and Mental Disease , 207  (5)   pp. 384-392.    10.1097/NMD.0000000000000981 <https://doi.org/10.1097/NMD.0000000000000981>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10067814/1/Cokal%20et%20al.%202019%20JNMD%20preprint.pdf