eprintid: 10067814 rev_number: 24 eprint_status: archive userid: 608 dir: disk0/10/06/78/14 datestamp: 2019-02-13 11:05:28 lastmod: 2021-09-20 22:28:26 status_changed: 2019-02-13 11:05:28 type: article metadata_visibility: show creators_name: Cokal, D creators_name: Zimmerer, V creators_name: Varley, R creators_name: Watson, S creators_name: Hinzen, W title: Comprehension of embedded clauses in schizophrenia with and without formal thought disorder ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D05 divisions: F71 keywords: Schizophrenia, Formal Thought Disorder, Comprehension, Syntax, Language dysfunction note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Formal thought disorder (FTD) in schizophrenia (SZ) is clinically manifest primarily through language production, where linguistic studies have reported numerous anomalies including lesser use of embedded clauses. Here we explored whether problems of language may extend to comprehension and clause embedding in particular. A sentence-picture matching task was designed with two conditions in which embedded clauses were either presupposed as true (factive) or not. Performance across these two conditions was compared in people with SZ and moderate-to-severe FTD (SZ+FTD), SZ with minimal FTD (SZ-FTD), first degree relatives of people with SZ, and neurotypical controls. The SZ+FTD group performed significantly worse than all others in both conditions, and worse in the non-factive than the factive one. These results demonstrate language dysfunction in comprehension specific to FTD in a critical aspect of grammatical complexity and its associated meaning, which has been independently known to be cognitively significant as well. date: 2019-05 date_type: published official_url: http://doi.org/10.1097/NMD.0000000000000981 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1628045 doi: 10.1097/NMD.0000000000000981 lyricists_name: Varley, Rosemary lyricists_name: Zimmerer, Vitor lyricists_id: RAVAR08 lyricists_id: VCZIM62 actors_name: Zimmerer, Vitor actors_id: VCZIM62 actors_role: owner full_text_status: public publication: The Journal of Nervous and Mental Disease volume: 207 number: 5 pagerange: 384-392 citation: Cokal, D; Zimmerer, V; Varley, R; Watson, S; Hinzen, W; (2019) Comprehension of embedded clauses in schizophrenia with and without formal thought disorder. The Journal of Nervous and Mental Disease , 207 (5) pp. 384-392. 10.1097/NMD.0000000000000981 <https://doi.org/10.1097/NMD.0000000000000981>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10067814/1/Cokal%20et%20al.%202019%20JNMD%20preprint.pdf