TY - JOUR N2 - Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg?=?0.57, p?=?4.6?×?10-8), breast and ovarian cancer (rg?=?0.24, p?=?7?×?10-5), breast and lung cancer (rg?=?0.18, p =1.5?×?10-6) and breast and colorectal cancer (rg?=?0.15, p?=?1.1?×?10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. SN - 2041-1723 A1 - Jiang, X A1 - Finucane, HK A1 - Schumacher, FR A1 - Schmit, SL A1 - Tyrer, JP A1 - Han, Y A1 - Michailidou, K A1 - Lesseur, C A1 - Kuchenbaecker, KB A1 - Dennis, J A1 - Conti, DV A1 - Casey, G A1 - Gaudet, MM A1 - Huyghe, JR A1 - Albanes, D A1 - Aldrich, MC A1 - Andrew, AS A1 - Andrulis, IL A1 - Anton-Culver, H A1 - Antoniou, AC A1 - Antonenkova, NN A1 - Arnold, SM A1 - Aronson, KJ A1 - Arun, BK A1 - Bandera, EV A1 - Barkardottir, RB A1 - Barnes, DR A1 - Batra, J A1 - Beckmann, MW A1 - Benitez, J A1 - Benlloch, S A1 - Berchuck, A A1 - Berndt, SI A1 - Bickeböller, H A1 - Bien, SA A1 - Blomqvist, C A1 - Boccia, S A1 - Bogdanova, NV A1 - Bojesen, SE A1 - Bolla, MK A1 - Brauch, H A1 - Brenner, H A1 - Brenton, JD A1 - Brook, MN A1 - Brunet, J A1 - Brunnström, H A1 - Buchanan, DD A1 - Burwinkel, B A1 - Butzow, R A1 - Cadoni, G A1 - Caldés, T A1 - Caligo, MA A1 - Campbell, I A1 - Campbell, PT A1 - Cancel-Tassin, G A1 - Cannon-Albright, L A1 - Campa, D A1 - Caporaso, N A1 - Carvalho, AL A1 - Chan, AT A1 - Chang-Claude, J A1 - Chanock, SJ A1 - Chen, C A1 - Christiani, DC A1 - Claes, KBM A1 - Claessens, F A1 - Clements, J A1 - Collée, JM A1 - Correa, MC A1 - Couch, FJ A1 - Cox, A A1 - Cunningham, JM A1 - Cybulski, C A1 - Czene, K A1 - Daly, MB A1 - deFazio, A A1 - Devilee, P A1 - Diez, O A1 - Gago-Dominguez, M A1 - Donovan, JL A1 - Dörk, T A1 - Duell, EJ A1 - Dunning, AM A1 - Dwek, M A1 - Eccles, DM A1 - Edlund, CK A1 - Edwards, DRV A1 - Ellberg, C A1 - Evans, DG A1 - Fasching, PA A1 - Ferris, RL A1 - Liloglou, T A1 - Figueiredo, JC A1 - Fletcher, O A1 - Fortner, RT A1 - Fostira, F A1 - Franceschi, S A1 - Friedman, E A1 - Gallinger, SJ A1 - Ganz, PA A1 - Garber, J A1 - García-Sáenz, JA A1 - Gayther, SA A1 - Giles, GG A1 - Godwin, AK A1 - Goldberg, MS A1 - Goldgar, DE A1 - Goode, EL A1 - Goodman, MT A1 - Goodman, G A1 - Grankvist, K A1 - Greene, MH A1 - Gronberg, H A1 - Gronwald, J A1 - Guénel, P A1 - Håkansson, N A1 - Hall, P A1 - Hamann, U A1 - Hamdy, FC A1 - Hamilton, RJ A1 - Hampe, J A1 - Haugen, A A1 - Heitz, F A1 - Herrero, R A1 - Hillemanns, P A1 - Hoffmeister, M A1 - Høgdall, E A1 - Hong, Y-C A1 - Hopper, JL A1 - Houlston, R A1 - Hulick, PJ A1 - Hunter, DJ A1 - Huntsman, DG A1 - Idos, G A1 - Imyanitov, EN A1 - Ingles, SA A1 - Isaacs, C A1 - Jakubowska, A A1 - James, P A1 - Jenkins, MA A1 - Johansson, M A1 - Johansson, M A1 - John, EM A1 - Joshi, AD A1 - Kaneva, R A1 - Karlan, BY A1 - Kelemen, LE A1 - Kühl, T A1 - Khaw, K-T A1 - Khusnutdinova, E A1 - Kibel, AS A1 - Kiemeney, LA A1 - Kim, J A1 - Kjaer, SK A1 - Knight, JA A1 - Kogevinas, M A1 - Kote-Jarai, Z A1 - Koutros, S A1 - Kristensen, VN A1 - Kupryjanczyk, J A1 - Lacko, M A1 - Lam, S A1 - Lambrechts, D A1 - Landi, MT A1 - Lazarus, P A1 - Le, ND A1 - Lee, E A1 - Lejbkowicz, F A1 - Lenz, H-J A1 - Leslie, G A1 - Lessel, D A1 - Lester, J A1 - Levine, DA A1 - Li, L A1 - Li, CI A1 - Lindblom, A A1 - Lindor, NM A1 - Liu, G A1 - Loupakis, F A1 - Lubi?ski, J A1 - Maehle, L A1 - Maier, C A1 - Mannermaa, A A1 - Marchand, LL A1 - Margolin, S A1 - May, T A1 - McGuffog, L A1 - Meindl, A A1 - Middha, P A1 - Miller, A A1 - Milne, RL A1 - MacInnis, RJ A1 - Modugno, F A1 - Montagna, M A1 - Moreno, V A1 - Moysich, KB A1 - Mucci, L A1 - Muir, K A1 - Mulligan, AM A1 - Nathanson, KL A1 - Neal, DE A1 - Ness, AR A1 - Neuhausen, SL A1 - Nevanlinna, H A1 - Newcomb, PA A1 - Newcomb, LF A1 - Nielsen, FC A1 - Nikitina-Zake, L A1 - Nordestgaard, BG A1 - Nussbaum, RL A1 - Offit, K A1 - Olah, E A1 - Olama, AAA A1 - Olopade, OI A1 - Olshan, AF A1 - Olsson, H A1 - Osorio, A A1 - Pandha, H A1 - Park, JY A1 - Pashayan, N A1 - Parsons, MT A1 - Pejovic, T A1 - Penney, KL A1 - Peters, WHM A1 - Phelan, CM A1 - Phipps, AI A1 - Plaseska-Karanfilska, D A1 - Pring, M A1 - Prokofyeva, D A1 - Radice, P A1 - Stefansson, K A1 - Ramus, SJ A1 - Raskin, L A1 - Rennert, G A1 - Rennert, HS A1 - van Rensburg, EJ A1 - Riggan, MJ A1 - Risch, HA A1 - Risch, A A1 - Roobol, MJ A1 - Rosenstein, BS A1 - Rossing, MA A1 - De Ruyck, K A1 - Saloustros, E A1 - Sandler, DP A1 - Sawyer, EJ A1 - Schabath, MB A1 - Schleutker, J A1 - Schmidt, MK A1 - Setiawan, VW A1 - Shen, H A1 - Siegel, EM A1 - Sieh, W A1 - Singer, CF A1 - Slattery, ML A1 - Sorensen, KD A1 - Southey, MC A1 - Spurdle, AB A1 - Stanford, JL A1 - Stevens, VL A1 - Stintzing, S A1 - Stone, J A1 - Sundfeldt, K A1 - Sutphen, R A1 - Swerdlow, AJ A1 - Tajara, EH A1 - Tangen, CM A1 - Tardon, A A1 - Taylor, JA A1 - Teare, MD A1 - Teixeira, MR A1 - Terry, MB A1 - Terry, KL A1 - Thibodeau, SN A1 - Thomassen, M A1 - Bjørge, L A1 - Tischkowitz, M A1 - Toland, AE A1 - Torres, D A1 - Townsend, PA A1 - Travis, RC A1 - Tung, N A1 - Tworoger, SS A1 - Ulrich, CM A1 - Usmani, N A1 - Vachon, CM A1 - Van Nieuwenhuysen, E A1 - Vega, A A1 - Aguado-Barrera, ME A1 - Wang, Q A1 - Webb, PM A1 - Weinberg, CR A1 - Weinstein, S A1 - Weissler, MC A1 - Weitzel, JN A1 - West, CML A1 - White, E A1 - Whittemore, AS A1 - Wichmann, H-E A1 - Wiklund, F A1 - Winqvist, R A1 - Wolk, A A1 - Woll, P A1 - Woods, M A1 - Wu, AH A1 - Wu, X A1 - Yannoukakos, D A1 - Zheng, W A1 - Zienolddiny, S A1 - Ziogas, A A1 - Zorn, KK A1 - Lane, JM A1 - Saxena, R A1 - Thomas, D A1 - Hung, RJ A1 - Diergaarde, B A1 - McKay, J A1 - Peters, U A1 - Hsu, L A1 - García-Closas, M A1 - Eeles, RA A1 - Chenevix-Trench, G A1 - Brennan, PJ A1 - Haiman, CA A1 - Simard, J A1 - Easton, DF A1 - Gruber, SB A1 - Pharoah, PDP A1 - Price, AL A1 - Pasaniuc, B A1 - Amos, CI A1 - Kraft, P A1 - Lindström, S AV - public IS - 1 N1 - Copyright © The Author(s) 2019 Open Access. 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TI - Shared heritability and functional enrichment across six solid cancers UR - http://doi.org/10.1038/s41467-018-08054-4 Y1 - 2019/01/25/ ID - discovery10067104 VL - 10 JF - Nature Communications ER -