%0 Journal Article %@ 2352-8737 %A Lutz, A %A Klimecki, OM %A Collette, F %A Poisnel, G %A Arenaza-Urquijo, E %A Marchant, NL %A De La Sayette, V %A Rauchs, G %A Salmon, E %A Vuilleumier, P %A Frison, E %A Vivien, D %A Chételat, G %D 2018 %F discovery:10065791 %J Alzheimer's and Dementia: Translational Research and Clinical Interventions %K Aging, Alzheimer's disease, Dementia, Prevention, Cognition, Reserve, Meditation expertise, Mindfulness meditation, Compassion and loving-kindness meditation, Emotion, Lifestyle, Neuroimaging, Blood markers, Sleep %P 756-764 %T The Age-Well observational study on expert meditators in the Medit-Ageing European project %U https://discovery.ucl.ac.uk/id/eprint/10065791/ %V 4 %X Introduction: The Age-Well observational, cross-sectional study investigates the affective and cognitive mechanisms of meditation expertise with behavioral, neuroimaging, sleep, and biological measures sensitive to aging and Alzheimer's disease (AD). Methods: Thirty cognitively unimpaired individuals aged 65 years or older with at least 10,000 hours of practice in mindfulness meditation (MM) and loving-kindness and compassion meditation (LKCM) are selected. The outcomes are the neuroimaging brain correlates of MM and LKCM and the assessments of long-term meditation practices on behavioral, neural, and biological measures as compared to nonmeditator older controls from the Age-Well randomized controlled trial. Results Recruitment and data collection began in late 2016 and will be completed by late 2019. Discussion: Results are expected to foster the understanding of the effects of meditation expertise on aging and of the mechanisms of action underlying the meditation intervention in the Age-Well randomized controlled trial. These finding will contribute to the design of meditation-based prevention randomized controlled trials for the aged population and to the exploration of the possible long-time developmental trajectory of meditation training. %Z Copyright © 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).