eprintid: 10065788
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/06/57/88
datestamp: 2019-01-16 19:24:31
lastmod: 2021-09-26 22:34:25
status_changed: 2019-01-16 19:24:31
type: article
metadata_visibility: show
creators_name: Campochiaro, C
creators_name: Atay, S
creators_name: Clark, KEN
creators_name: Ong, V
creators_name: Denton, CP
title: Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G90
keywords: connective tissue disease, immunology
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Selective immunoglobulin M deficiency (sIgMD) is an immunodeficiency with undefined pathogenesis and commonly presenting with recurrent infections. 1 The European Society for Immunodeficiencies Registry defines sIgMD as a serum IgM level repeatedly below 2 SD of normal with normal levels of serum IgA, IgG and IgG subclasses, normal vaccination responses, absence of T-cell defects and absence of causative external factors. Rarely it can also be associated with autoimmune diseases. 2-7 Here we describe a patient with primary sIgMD; who presented with multiple autoimmune diseases without a history of recurrent infections and we provide a short literature review on sIgMD and autoimmune diseases.
date: 2019-01-03
date_type: published
official_url: http://dx.doi.org/10.1136/bcr-2017-223180
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1620125
doi: 10.1136/bcr-2017-223180
pii: 12/1/e223180
lyricists_name: Clark, Kristina
lyricists_name: Denton, Christopher
lyricists_name: Ong, Voon
lyricists_id: KENCL47
lyricists_id: CPDEN87
lyricists_id: VONGX45
actors_name: Denton, Christopher
actors_id: CPDEN87
actors_role: owner
full_text_status: public
publication: BMJ Case Reports
volume: 12
number: 1
article_number: e223180
event_location: England
issn: 1757-790X
citation:        Campochiaro, C;    Atay, S;    Clark, KEN;    Ong, V;    Denton, CP;      (2019)    Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency.                   BMJ Case Reports , 12  (1)    , Article e223180.  10.1136/bcr-2017-223180 <https://doi.org/10.1136/bcr-2017-223180>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10065788/1/Accepted%20version%20BMJ%20CR%202018.pdf